For chemists and researchers engaged in organic synthesis, understanding the fundamental properties and reliable synthesis routes of key intermediates is crucial. Ethyl 4-bromo-2-fluorobenzoate (CAS: 474709-71-2) is a significant fluoroaromatic compound, valued for its utility as a versatile building block. This article aims to provide a clear overview of its chemical characteristics and common synthesis methods, from the perspective of a dedicated chemical supplier.

Ethyl 4-bromo-2-fluorobenzoate is typically encountered as a clear, colorless liquid. Its molecular formula is C9H8BrFO2, with a molecular weight of approximately 247.06 g/mol. Key physical properties, such as its boiling point, are reported to be around 287.8 ± 25.0 °C, and its density is approximately 1.504 ± 0.06 g/cm³. These characteristics are important for handling, storage, and purification procedures in both laboratory and industrial settings. Proper storage, usually sealed in a dry environment at room temperature, helps maintain its integrity. When you need to buy this compound, understanding these properties assists in its effective application.

The synthesis of Ethyl 4-bromo-2-fluorobenzoate commonly involves the esterification of 4-bromo-2-fluorobenzoic acid. A typical route includes reacting the corresponding acid with ethanol in the presence of a coupling agent and a catalyst. For instance, using reagents like EDCI (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride) and DMAP (4-dimethylaminopyridine) in a solvent such as dichloromethane (DCM) can efficiently yield the desired ethyl ester. The reaction mixture is then processed, often involving aqueous washes, drying, and purification via column chromatography to obtain the product in high yield and purity. As a reputable manufacturer, we meticulously control these synthesis steps to ensure the quality of the Ethyl 4-bromo-2-fluorobenzoate we supply.

The utility of Ethyl 4-bromo-2-fluorobenzoate lies in its reactive functional groups. The bromine atom is an excellent leaving group for nucleophilic substitution and is particularly useful in palladium-catalyzed cross-coupling reactions. The ester group can be hydrolyzed to the carboxylic acid or reduced to an alcohol, offering further synthetic flexibility. The fluorine atom, as previously mentioned, can impart desirable properties to the final molecule. This versatility makes it a valuable intermediate for researchers and companies looking to innovate in pharmaceuticals, agrochemicals, and materials science. We encourage you to request a quote for this versatile intermediate from our facility in China.

When sourcing chemical intermediates, selecting a knowledgeable and reliable supplier is critical. Our company is dedicated to providing researchers and manufacturers with high-quality Ethyl 4-bromo-2-fluorobenzoate, backed by our expertise in chemical synthesis. We invite you to connect with us to buy this compound and benefit from our competitive pricing and dependable supply chain. Your project’s success is our priority.