For scientists and procurement specialists in the chemical industry, a thorough understanding of key intermediates is vital for successful project execution. Methyl 2-Bromo-4-Fluorobenzoate (CAS: 653-92-9) is one such compound, recognized for its significant utility in organic synthesis, particularly within the pharmaceutical sector. This article aims to provide a comprehensive overview of its properties, common synthesis routes, and guidance on how to efficiently purchase this valuable chemical from reliable manufacturers.

Methyl 2-Bromo-4-Fluorobenzoate is a halogenated aromatic ester, typically supplied as an off-white powder. Its chemical formula is C8H6BrFO2, and its CAS Registry Number is 653-92-9. The compound's structure, featuring a bromine atom at the ortho position and a fluorine atom at the para position relative to the methyl ester group, dictates its reactivity. This specific arrangement of substituents makes it a highly versatile building block in complex organic reactions. Its boiling point is approximately 75-78°C at 1 mm, and it has a flash point of 100°C.

The synthesis of Methyl 2-Bromo-4-Fluorobenzoate commonly involves the esterification of 2-bromo-4-fluorobenzoic acid. A typical laboratory synthesis might involve reacting the carboxylic acid with an alcohol, such as methanol, in the presence of an acid catalyst, or via activation of the carboxylic acid using reagents like thionyl chloride followed by reaction with methanol. Another common method described in literature involves using reagents like iodomethane and a base such as DBU in acetonitrile. As a manufacturer, we optimize these processes to ensure high yield and exceptional purity, typically achieving a minimum of 98%.

The applications of Methyl 2-Bromo-4-Fluorobenzoate are diverse, but its primary role is as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its functional groups allow for participation in a wide range of coupling reactions, such as Suzuki-Miyaura, Heck, and Buchwald-Hartwig couplings, which are fundamental in constructing complex molecular architectures. For example, it can be used to synthesize novel compounds with potential therapeutic applications, including anti-cancer agents or anti-inflammatory drugs. Researchers often buy this compound for its predictable reactivity and its ability to introduce desirable fluorinated aromatic motifs into target molecules.

When sourcing Methyl 2-Bromo-4-Fluorobenzoate, it is crucial to partner with a reputable manufacturer and supplier. Factors to consider include product purity, batch-to-batch consistency, packaging options, and responsive customer service. We, as a manufacturer based in China, are committed to providing high-quality Methyl 2-Bromo-4-Fluorobenzoate with guaranteed purity and competitive pricing. Our goal is to support your research and development endeavors by ensuring you have access to the essential chemical building blocks you need.

In summary, understanding the properties and synthesis of Methyl 2-Bromo-4-Fluorobenzoate is key for chemists and procurement specialists. By selecting a reliable supplier, you can ensure the successful execution of your synthetic projects and contribute to advancements in medicinal chemistry and beyond. We encourage you to consider our offerings when you need to buy this vital intermediate.