Understanding Purity: N-Methyl-1-Naphthalenemethanamine Specifications for Pharma
In the pharmaceutical industry, the quality of every component, especially intermediates, directly impacts the efficacy and safety of the final drug product. N-Methyl-1-Naphthalenemethanamine (CAS 14489-75-9) is a critical pharmaceutical intermediate, and its specifications are therefore rigorously defined and meticulously checked. Understanding these details is essential for procurement specialists and R&D scientists seeking a reliable supplier.
The primary specification for N-Methyl-1-Naphthalenemethanamine is its purity. Typically, pharmaceutical-grade material will have a purity of ≥98.0% as determined by Gas Chromatography (GC). This high level of purity is crucial because even minor impurities can interfere with subsequent synthesis steps, potentially leading to reduced yields, product degradation, or the formation of undesired byproducts that could compromise the final API's quality. When inquiring about this product, always confirm the method of analysis (e.g., GC, HPLC) and the reported purity.
Beyond purity, physical properties are also important for handling and processing. N-Methyl-1-Naphthalenemethanamine is commonly described as an achromatous or light yellow oily liquid at normal room temperatures. However, it is noted that it can solidify easily in cold circumstances. This characteristic means that suppliers should provide guidance on appropriate storage conditions, usually in a cool, dry, well-closed container, protected from moisture and extreme temperatures, to maintain its liquid state or facilitate easy remelting.
Other specifications, such as isomer content and the presence of specific impurities, might also be detailed by manufacturers. For instance, the reference to it being an intermediate for Terbinafine Hydrochloride synthesis implies that its compliance with the stringent requirements for such an application is vital. When seeking a manufacturer or supplier, detailed technical data sheets and certificates of analysis are indispensable tools for quality assurance and risk mitigation in the pharmaceutical supply chain.
Perspectives & Insights
Molecule Vision 7
“Other specifications, such as isomer content and the presence of specific impurities, might also be detailed by manufacturers.”
Alpha Origin 24
“For instance, the reference to it being an intermediate for Terbinafine Hydrochloride synthesis implies that its compliance with the stringent requirements for such an application is vital.”
Future Analyst X
“When seeking a manufacturer or supplier, detailed technical data sheets and certificates of analysis are indispensable tools for quality assurance and risk mitigation in the pharmaceutical supply chain.”