For pharmaceutical professionals dedicated to oral solid dosage (OSD) formulation, the selection of the right excipients is a cornerstone of product development. Among the most versatile and effective choices is Copovidone PVP/VA S-630. This copolymer has carved out a significant niche due to its multifaceted benefits, ranging from robust tablet binding to enhancing the solubility of challenging Active Pharmaceutical Ingredients (APIs). As a premier manufacturer and supplier of pharmaceutical intermediates, we are committed to providing OSD formulators with high-quality Copovidone PVP/VA S-630.

Copovidone PVP/VA S-630 is a 60:40 random copolymer of N-vinyl-2-pyrrolidone and vinyl acetate. This specific ratio is crucial, as it balances the hydrophilic nature and binding capabilities of polyvinylpyrrolidone (PVP) with the reduced hygroscopicity and modified glass transition temperature (Tg) introduced by vinyl acetate. This optimization makes it particularly suitable for OSD applications where tablet integrity, dissolution profile, and stability are paramount.

One of the primary functions of Copovidone PVP/VA S-630 in OSD is its role as a binder. When used in direct compression or dry granulation processes, it imparts excellent compressibility to the powder mixture. This leads to the formation of tablets that are strong and resistant to chipping or breaking during handling, packaging, and transport. For pharmaceutical manufacturers looking to buy reliable binding agents, our Copovidone PVP/VA S-630 offers consistent performance, ensuring batch-to-batch reproducibility – a critical factor for regulatory approval and product quality.

Beyond its mechanical benefits, the solubilizing properties of this copolymer are increasingly vital. Many new chemical entities exhibit poor water solubility, posing a significant challenge for oral bioavailability. Copovidone PVP/VA S-630 can form solid dispersions with these poorly soluble APIs, thereby increasing their surface area and promoting faster dissolution. This makes it an invaluable tool for formulators aiming to improve the therapeutic efficacy of their drug products. We offer this product at competitive prices for bulk purchase, enabling wider adoption in solubility-enhancing formulations.

Furthermore, the polymer's film-forming capabilities are beneficial for tablet coating applications, where it can contribute to the integrity and appearance of the coated dosage form. Its compatibility with various other excipients commonly used in OSD formulations—such as fillers, disintegrants, and lubricants—ensures its seamless integration into complex formulations.

For pharmaceutical companies worldwide seeking to buy high-quality Copovidone PVP/VA S-630, partnering with a reputable China manufacturer like us provides a reliable and cost-effective solution. We understand the stringent demands of the pharmaceutical industry and are dedicated to supplying a product that meets the highest standards of purity and performance. Contact us today to request a quote and explore how our Copovidone PVP/VA S-630 can enhance your next OSD development project.