For professionals in the chemical and pharmaceutical sectors, ensuring the quality of raw materials is a critical step in every process. 3-(3,4,5-Trimethoxyphenyl)propionic acid (CAS 25173-72-2) is no exception. As a key pharmaceutical intermediate, its purity and consistency directly impact downstream synthesis. This guide outlines a buyer's checklist for quality assurance when procuring this compound.

Key Quality Parameters to Verify

When purchasing 3-(3,4,5-Trimethoxyphenyl)propionic acid, several quality parameters are paramount. The compound's chemical formula is C12H16O5, and its molecular weight is 240.25. The most critical specification is typically its assay, which should ideally be 99.5%min for pharmaceutical applications. Beyond assay, consider:

  • Appearance: It should generally be a white to almost white crystalline powder.
  • Solubility: Refer to specifications for solubility in common solvents like methanol, which is often listed as clear at 0.1 g/mL.
  • Melting Point: While variations exist, literature often cites a melting point around 100-104 °C.
  • Impurity Profile: Reputable manufacturers will provide information on known impurities and their acceptable limits.

The Role of Documentation: CoA and SDS

A comprehensive Certificate of Analysis (CoA) is your primary tool for verifying quality. A reliable supplier will provide a CoA for each batch of 3-(3,4,5-Trimethoxyphenyl)propionic acid, detailing the results of various quality tests, including assay, appearance, and relevant analytical data (e.g., NMR, HPLC). Equally important is the Safety Data Sheet (SDS), which provides crucial information on handling, storage, and potential hazards.

Supplier Vetting: More Than Just Price

While competitive pricing is important, especially when buying in bulk (e.g., 25kg drums with a 1kg minimum order quantity), it should not overshadow quality assurance. When sourcing from manufacturers and suppliers, especially in regions like China, consider:

  • Manufacturer's Reputation: Look for established companies with a proven track record in producing pharmaceutical intermediates.
  • Quality Management Systems: While not always explicitly stated for specific products, adherence to standards like ISO can be an indicator.
  • Customer Reviews and Testimonials: Feedback from other buyers can offer insights into a supplier's reliability and product consistency.
  • Communication and Responsiveness: A supplier who promptly answers questions about specifications and provides necessary documentation is usually a better partner.

By diligently checking these quality assurance points and partnering with reputable manufacturers and suppliers, you can ensure that your supply of 3-(3,4,5-Trimethoxyphenyl)propionic acid meets the high standards required for your critical chemical synthesis and pharmaceutical development projects.