In the pharmaceutical and fine chemical industries, the quality of raw materials is non-negotiable. For intermediates like 3-Amino-3-(3-fluorophenyl)propionic Acid (CAS: 117391-51-2), ensuring consistent high purity is paramount for successful synthesis and downstream applications. This guide is designed for R&D scientists and procurement professionals seeking to understand how to verify the quality of this compound when they buy it from various suppliers.

The Critical Role of Purity

3-Amino-3-(3-fluorophenyl)propionic Acid is often used in sensitive applications, particularly in the early stages of drug development. Impurities, even at low levels, can interfere with reactions, lead to the formation of unwanted by-products, or affect the efficacy and safety profile of the final product. Therefore, a purity level exceeding 97% is commonly required by researchers and manufacturers. Understanding the analytical methods used to determine purity is key.

Key Quality Documentation: The Certificate of Analysis (CoA)

The Certificate of Analysis (CoA) is the primary document provided by a manufacturer that attests to the quality of a chemical product. For 3-Amino-3-(3-fluorophenyl)propionic Acid, a comprehensive CoA should include:

  • Product Identification: Name, CAS number (117391-51-2), and molecular formula (C9H10FNO2).
  • Purity Assay: The specific percentage of the desired compound, typically determined by techniques like High-Performance Liquid Chromatography (HPLC) or Nuclear Magnetic Resonance (NMR) spectroscopy. Look for specifications clearly stating '>97%' or higher.
  • Impurities Profile: Identification and quantification of any significant impurities.
  • Physical Characteristics: Appearance (e.g., white to off-white solid or powder) and melting point (around 210-212°C).
  • Analytical Methods Used: Information on how the purity and other parameters were determined.
  • Batch Number and Date of Analysis: Essential for traceability and quality assurance.

It is always advisable to request a batch-specific CoA when placing an order. Many reputable suppliers also provide spectral data, such as 1H NMR and 13C NMR, which can further confirm the compound's structure and purity.

Supplier Reliability and Trust

Beyond the CoA, the reputation and practices of the supplier play a crucial role in quality assurance. When you purchase from a trusted source, you gain confidence in the product's integrity. Look for suppliers who:

  • Are transparent about their manufacturing processes and quality control protocols.
  • Have positive customer reviews and a history of reliable supply.
  • Are willing to provide samples for your own verification before committing to large orders.
  • Maintain clear communication channels for addressing any quality concerns.

As a dedicated supplier of pharmaceutical intermediates, we prioritize stringent quality control at every stage of production. Our commitment ensures that you receive 3-Amino-3-(3-fluorophenyl)propionic Acid that meets your exacting standards, allowing you to focus on your research and development without concerns about material quality.

In conclusion, maintaining a keen eye on quality documentation and choosing reputable suppliers are the cornerstones of successfully sourcing critical intermediates like 3-Amino-3-(3-fluorophenyl)propionic Acid. By following these guidelines, R&D professionals and procurement managers can ensure the integrity and efficacy of their synthetic endeavors.