Retinoic Acid, commonly known by its CAS number 302-79-4 and the alias Tretinoin, is a powerhouse compound with significant utility across research, pharmaceutical, and cosmetic industries. As a vital metabolite of Vitamin A, it plays a critical role in cellular differentiation, growth, and a variety of biological processes. Understanding its fundamental properties and broad applications is essential for anyone in the chemical procurement, research and development, or product formulation sectors.

Chemical Profile and Properties of Retinoic Acid

Retinoic Acid (Tretinoin) is an oxidized carboxylic acid form of retinol. Its chemical formula is C20H28O2, and it has a molecular weight of approximately 300.43 g/mol. Physically, it typically presents as a yellow to light orange crystalline powder. Its solubility profile is notable: it is soluble in organic solvents like DMSO, ethanol, and chloroform, but practically insoluble in water. This characteristic is important for its formulation in various topical and chemical applications. The compound is also sensitive to light, necessitating proper storage conditions, often in a cool, dark environment.

Mechanism of Action and Biological Significance

The primary mechanism of Retinoic Acid involves binding to specific nuclear receptors, namely the Retinoic Acid Receptors (RARs) and Retinoid X Receptors (RXRs). Upon binding, it modulates gene expression, influencing crucial cellular processes such as differentiation, proliferation, and apoptosis. This direct impact on cellular regulation is the basis for its therapeutic efficacy in treating conditions ranging from acne to certain types of leukemia, and its benefits in improving skin texture and appearance.

Key Applications Across Industries

  • Dermatology: Tretinoin is a well-established treatment for acne vulgaris, effectively unclogging pores and reducing inflammation. It is also a leading ingredient for combating photoaging, smoothing wrinkles, and improving skin tone.
  • Oncology: In the medical field, Tretinoin is a vital component in the treatment of acute promyelocytic leukemia (APL), promoting the maturation of cancer cells.
  • Cosmetics: Beyond prescription treatments, Tretinoin is a prized active ingredient in over-the-counter skincare products aimed at anti-aging and skin rejuvenation.
  • Research and Development: Its well-defined biological activity makes it a valuable compound for cellular signaling studies, drug discovery, and various biochemical research applications.

Sourcing High-Quality Retinoic Acid

For formulators and researchers, sourcing Retinoic Acid (Tretinoin) from a reliable supplier is paramount. Ensuring high purity (e.g., >98%) and consistent quality is essential for predictable results. When you buy Retinoic Acid or Tretinoin powder, consider working with experienced manufacturers and suppliers in China who can offer competitive pricing and dependable delivery. Always verify the CAS number (302-79-4) and request Certificates of Analysis to confirm product specifications.

As your dedicated chemical supplier, we provide premium-grade All-Trans Retinoic Acid to meet your diverse needs. We are committed to offering the quality and reliability required for your critical applications.