In the intricate world of pharmaceutical synthesis, certain chemical intermediates stand out for their indispensable role in creating life-changing medications. (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol, identified by CAS 225920-05-8, is one such compound. Its unique molecular structure and chirality make it a key building block, most notably in the production of Aprepitant. For R&D scientists and procurement specialists looking to buy this chemical, understanding its significance is crucial.

(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol is a fluorinated chiral alcohol. The trifluoromethyl groups (CF3) impart lipophilicity and metabolic stability to molecules, properties often desirable in drug design. The '1S' designation refers to its specific stereochemistry at the chiral center, which is critical because biological systems are highly sensitive to molecular shape. Incorrect stereoisomers can lead to reduced efficacy or even adverse effects. Therefore, sourcing this intermediate with the correct chirality is non-negotiable for pharmaceutical applications.

The most prominent application of (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol is as a precursor to Aprepitant. Aprepitant is a substance P/neurokinin-1 (NK1) receptor antagonist used to prevent chemotherapy-induced nausea and vomiting (CINV). The synthesis pathway from this intermediate to Aprepitant involves several carefully controlled chemical transformations, where the precise structure and purity of (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol directly influence the yield and quality of the final active pharmaceutical ingredient (API). Consequently, pharmaceutical manufacturers prioritize suppliers who can consistently deliver this intermediate with high purity and the correct stereochemical configuration.

Beyond Aprepitant, this versatile fluorinated intermediate can be employed in the synthesis of other novel drug candidates. Its trifluoromethylated phenyl ethanol structure provides a useful scaffold for medicinal chemists exploring new therapeutic agents targeting various diseases. When researchers look to buy this compound for their R&D projects, they are often seeking a reliable source that can provide consistent quality and technical support.

The availability of high-quality (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol from manufacturers, especially those in China, has made it more accessible for the global pharmaceutical industry. These suppliers are equipped to handle the synthesis of such complex molecules, ensuring that the required stereochemistry and purity standards are met. For any company engaged in the synthesis of Aprepitant or related compounds, establishing a partnership with a dependable manufacturer of this intermediate is a strategic imperative.

In summary, (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol plays a pivotal role in modern pharmaceutical synthesis. Its specific chiral structure and the presence of trifluoromethyl groups make it an invaluable intermediate, particularly for Aprepitant production. Understanding its chemical significance and sourcing it from reputable suppliers ensures the success and integrity of drug manufacturing processes. We are a dedicated supplier committed to providing this essential intermediate.