In the realm of advanced chemical manufacturing, the selection of appropriate intermediates dictates the efficiency, purity, and ultimate success of complex synthesis projects. (1S,4R)-p-Menth-2,8-dien-1-ol, identified by its CAS number 22972-51-6, has emerged as a critical fine chemical intermediate, especially in the pharmaceutical industry. For procurement specialists and research scientists, understanding its properties, synthesis pathways, and market availability is crucial for strategic acquisition. As a global manufacturer and supplier, we aim to provide clarity on this important compound.

Understanding (1S,4R)-p-Menth-2,8-dien-1-ol: Properties and Synthesis

(1S,4R)-p-Menth-2,8-dien-1-ol is characterized as a white solid with a molecular formula of C10H16O and a molecular weight of 152.23 g/mol. Its structure is a derivative of limonene, a common terpene. The synthesis of this compound often involves sophisticated chemical transformations, with various methods detailed in scientific literature. For example, certain preparative routes involve the use of limonene as a starting material, undergoing steps such as halogenation, reaction with tertiary amines, and subsequent pyrolysis elimination, or employing photooxygenation techniques. The yield and purity achieved can vary significantly depending on the chosen methodology, emphasizing the importance of sourcing from manufacturers with optimized and well-controlled synthesis processes. A minimum purity of 98.0% is typically expected for its primary applications.

Key Applications in Pharmaceutical and Chemical Industries

The most prominent application of (1S,4R)-p-Menth-2,8-dien-1-ol is its role as a key intermediate in the synthesis of cannabidiol (CBD). CBD is highly valued for its therapeutic properties, including its anti-spasmodic, anti-anxiety, anti-inflammatory, and analgesic effects. The compound's stereochemistry is vital for the efficient and targeted synthesis of CBD. Beyond CBD, this versatile intermediate finds use in the broader field of organic synthesis, serving as a building block for various complex molecules and potential drug candidates. Its involvement in creating compounds with CNS-active properties further underscores its significance in pharmaceutical R&D.

Strategic Procurement: Sourcing from Manufacturers

For businesses looking to purchase (1S,4R)-p-Menth-2,8-dien-1-ol, establishing a relationship with a reliable manufacturer is paramount. When considering global sourcing, manufacturers in China offer competitive pricing and large-scale production capabilities. It is essential for procurement managers to work with suppliers who adhere to strict quality control measures, can provide comprehensive documentation (such as SDS and TDS), and offer flexible packaging options, typically in 25kg bags or fiber drums. Inquiring about pricing for bulk orders and seeking samples for preliminary testing are standard practices to ensure suitability for specific industrial processes. Focusing on suppliers with a strong reputation for consistency and service is key to a secure supply chain.

Future Outlook and Market Demand

The demand for high-purity intermediates like (1S,4R)-p-Menth-2,8-dien-1-ol is projected to grow, driven by the expanding markets for CBD and novel pharmaceuticals. Companies that can consistently supply this compound with guaranteed quality and at competitive prices will be well-positioned to meet this demand. For R&D scientists, understanding the synthetic pathways and potential applications of this intermediate can unlock new avenues for drug discovery and product innovation. As a manufacturer, we are committed to supporting these advancements by providing access to this critical chemical building block.

In conclusion, (1S,4R)-p-Menth-2,8-dien-1-ol is an indispensable intermediate in modern chemical manufacturing, particularly for the pharmaceutical sector. Its strategic sourcing from reputable manufacturers ensures quality and cost-effectiveness, paving the way for advancements in therapeutic compound development.