The intricate pathways of cellular signaling often hinge on key molecular players, and in the realm of nitric oxide biology, 2-Amino-4-methoxypyridine (CAS: 10201-73-7) has emerged as a compound of significant interest. For researchers dedicated to understanding inflammation, immunology, and disease pathology, obtaining high-quality pharmaceutical intermediates like this is fundamental. This article delves into its scientific significance and guides you on how to effectively purchase it from reputable sources.

Understanding Nitric Oxide Synthase (NOS)

Nitric oxide (NO) is a crucial signaling molecule involved in a wide array of physiological processes, including vasodilation, neurotransmission, and immune responses. Nitric oxide synthases (NOS) are enzymes responsible for its production. There are three main isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS). While nNOS and eNOS produce NO constitutively at low levels, iNOS is upregulated during inflammatory states, leading to the production of large amounts of NO, which can be both beneficial for pathogen clearance and detrimental, contributing to tissue damage.

2-Amino-4-methoxypyridine: A Selective iNOS Inhibitor

Research has identified 2-Amino-4-methoxypyridine as a potent and highly selective inhibitor of iNOS. This selectivity is critical because inhibiting all NOS isoforms would have widespread and undesirable physiological effects. By targeting iNOS specifically, this compound allows researchers to probe the role of iNOS-derived NO in various disease models without significantly impacting normal physiological functions regulated by nNOS and eNOS. If your research involves studying inflammatory diseases, sepsis, or neuroinflammation, incorporating this compound into your experimental design can yield valuable insights.

Procurement for Research: Quality and Supplier Choice

To effectively utilize 2-Amino-4-methoxypyridine in your laboratory, sourcing it from a reliable manufacturer is essential. When you decide to buy this chemical, prioritize suppliers who offer:

  • High Purity: Ensure the product meets stringent purity requirements for biochemical assays and synthetic procedures. A purity of 97% or higher is typically recommended.
  • Comprehensive Documentation: Request a Certificate of Analysis (CoA) detailing purity, identity, and other relevant specifications, along with an SDS for safe handling.
  • Competitive Pricing: Compare prices from various suppliers to ensure you are obtaining good value for your investment. Bulk purchase options and discounts are often available for research institutions.
  • Reputable Supply Chain: Opt for suppliers with a strong reputation in the fine chemical and pharmaceutical intermediate market, especially those based in regions known for chemical manufacturing excellence, like China.

For scientists looking to investigate the complex roles of nitric oxide in health and disease, 2-Amino-4-methoxypyridine presents itself as an invaluable tool. By carefully selecting your supplier and understanding the product's specifications, you can ensure the success of your research endeavors. We encourage you to reach out for a quote and sample to assess our capabilities as your trusted supplier.