In the complex world of chemical manufacturing, certain compounds stand out for their crucial roles in enabling the production of vital end products. 2-Butyl-5-nitrobenzofuran (CAS 133238-87-6) is one such molecule, primarily recognized for its indispensable position as an intermediate in the synthesis of Dronedarone, an important antiarrhythmic drug. This article delves into the chemical characteristics and diverse applications of 2-Butyl-5-nitrobenzofuran, highlighting its importance for researchers and industrial buyers, and emphasizing the benefits of sourcing from reliable manufacturers and suppliers.

Chemical Profile of 2-Butyl-5-nitrobenzofuran

2-Butyl-5-nitrobenzofuran, with the molecular formula C12H13NO3 and a molecular weight of 219.24 g/mol, is characterized by its benzofuran core substituted with a butyl group and a nitro group. Its CAS number, 133238-87-6, serves as a unique identifier for this specialty chemical. Typically presented as a pale yellow to yellow solid or liquid, its purity is often specified at 98% or higher, which is a critical parameter for its use in pharmaceutical synthesis. The compound’s structure makes it a versatile precursor for further chemical modifications.

Primary Application: Dronedarone Synthesis

The most significant application of 2-Butyl-5-nitrobenzofuran is as a key intermediate in the multi-step manufacturing process of Dronedarone. Dronedarone hydrochloride is a Class III antiarrhythmic medication used to treat atrial fibrillation and atrial flutter. The efficient and high-purity synthesis of Dronedarone relies heavily on the quality of its precursors. Therefore, pharmaceutical companies and contract manufacturing organizations (CMOs) actively seek out reliable suppliers who can provide 2-Butyl-5-nitrobenzofuran that meets stringent quality specifications. Sourcing this intermediate from reputable manufacturers in China offers an opportunity to secure a cost-effective supply chain.

Beyond Pharmaceuticals: Cosmetic and Research Uses

While its pharmaceutical role is primary, 2-Butyl-5-nitrobenzofuran also finds application in the cosmetics industry. Its chemical properties may lend themselves to specific formulations, although detailed applications in this sector are less publicized. Furthermore, for research and development laboratories, 2-Butyl-5-nitrobenzofuran serves as a valuable building block in various organic synthesis projects. Researchers exploring new synthetic routes or developing novel compounds may buy 2-butyl-5-nitrobenzofuran for their experimental work.

Sourcing Strategies for Buyers

For any business looking to buy 2-butyl-5-nitrobenzofuran, a strategic sourcing approach is vital. Identifying trustworthy manufacturers and suppliers, particularly those based in China, requires diligence. Key aspects to consider include:

  • Supplier Verification: Prioritize suppliers who can provide batch-specific Certificates of Analysis (CoA) detailing purity and characterization data.
  • Production Capacity: Ensure the supplier can consistently deliver the required quantities, whether for R&D or large-scale manufacturing.
  • Competitive Pricing: Obtain quotations from multiple sources to ensure you are getting a fair price. Understand the total cost of ownership, including shipping and potential import duties.
  • Technical Support: Good suppliers offer technical assistance and responsive customer service, crucial for navigating complex chemical procurement.

As a significant intermediate, the availability and quality of 2-Butyl-5-nitrobenzofuran directly impact the pharmaceutical industry's ability to produce essential medications. By understanding its applications and implementing sound sourcing strategies, businesses can ensure a stable supply of this critical chemical. If you're in the market to purchase this intermediate, connecting with a reliable manufacturer in China is often the most efficient route.