The Role of 2-Chloro-5-nitro-pyridin-4-ol in Pharmaceutical Synthesis
The pharmaceutical industry is in continuous pursuit of novel therapeutic agents, a quest heavily reliant on the availability of advanced chemical building blocks. Among these, specialized intermediates play a pivotal role, enabling the intricate synthesis of complex drug molecules. 2-Chloro-5-nitro-pyridin-4-ol (CAS: 1211386-69-4) has emerged as a significant compound in this domain, valued for its unique chemical structure and reactivity, making it a crucial pharmaceutical intermediate. This article examines its contributions to drug discovery and synthesis, emphasizing the importance of reliable sourcing from a reputable 2-Chloro-5-nitro-pyridin-4-ol manufacturer in China.
Chemical Profile of 2-Chloro-5-nitro-pyridin-4-ol
This compound, appearing as a light yellow crystalline powder, possesses a molecular formula of C5H3ClN2O3 and a molecular weight of 174.54200. Its physical and chemical properties, including a density of approximately 1.664±0.06 g/cm³, are well-documented. Crucially, its purity level typically exceeds 98.0%, a standard that is non-negotiable for pharmaceutical applications where even minute impurities can compromise the efficacy and safety of the final drug product.
The pyridine core, functionalized with a chlorine atom at the 2-position, a nitro group at the 5-position, and a hydroxyl group at the 4-position, provides multiple sites for chemical modification. The chloro substituent is susceptible to nucleophilic displacement, the nitro group can be readily reduced to an amino group, and the hydroxyl group can undergo various esterification or etherification reactions. These reactive centers are precisely what make 2-Chloro-5-nitro-pyridin-4-ol such a valuable intermediate in multi-step synthetic pathways common in drug development.
Contribution to Drug Discovery and Development
In pharmaceutical research, intermediates like 2-Chloro-5-nitro-pyridin-4-ol are instrumental in building complex molecular scaffolds. Researchers can leverage its structure to introduce specific functionalities or to extend carbon chains, ultimately synthesizing compounds with potential therapeutic activities. For example, the transformation of the nitro group into an amine opens avenues for creating amide linkages or for further heterocyclic ring formations, both common motifs in many active pharmaceutical ingredients (APIs).
The development of targeted therapies often requires fine-tuning the chemical structure of lead compounds. The presence of multiple reactive sites on 2-Chloro-5-nitro-pyridin-4-ol allows for systematic modifications, enabling medicinal chemists to optimize a compound’s potency, selectivity, pharmacokinetic profile, and metabolic stability. This capability significantly accelerates the drug discovery pipeline.
Why Partner with a China-Based Manufacturer?
For pharmaceutical companies and research institutions, securing a consistent supply of high-quality 2-Chloro-5-nitro-pyridin-4-ol is paramount. Manufacturers in China have become significant players in the global chemical supply chain, offering competitive pricing and advanced production capabilities. Engaging with a trusted 2-Chloro-5-nitro-pyridin-4-ol supplier in China ensures access to a reliable source of this essential intermediate, backed by stringent quality control measures.
The importance of proper handling and storage cannot be overstated. Storing 2-Chloro-5-nitro-pyridin-4-ol in a cool, dry, and well-ventilated environment is critical to maintain its chemical integrity and prevent degradation. Following standard laboratory safety protocols when working with this compound is also a necessary measure.
Conclusion
2-Chloro-5-nitro-pyridin-4-ol is more than just a chemical compound; it is a key enabler of innovation in the pharmaceutical sector. Its versatile reactivity and high purity make it an indispensable tool for drug discovery and development. By partnering with experienced manufacturers like NINGBO INNO PHARMCHEM CO.,LTD., research institutions and pharmaceutical companies can secure a reliable supply of this vital intermediate, accelerating their progress towards creating life-saving medicines.
Chemical Profile of 2-Chloro-5-nitro-pyridin-4-ol
This compound, appearing as a light yellow crystalline powder, possesses a molecular formula of C5H3ClN2O3 and a molecular weight of 174.54200. Its physical and chemical properties, including a density of approximately 1.664±0.06 g/cm³, are well-documented. Crucially, its purity level typically exceeds 98.0%, a standard that is non-negotiable for pharmaceutical applications where even minute impurities can compromise the efficacy and safety of the final drug product.
The pyridine core, functionalized with a chlorine atom at the 2-position, a nitro group at the 5-position, and a hydroxyl group at the 4-position, provides multiple sites for chemical modification. The chloro substituent is susceptible to nucleophilic displacement, the nitro group can be readily reduced to an amino group, and the hydroxyl group can undergo various esterification or etherification reactions. These reactive centers are precisely what make 2-Chloro-5-nitro-pyridin-4-ol such a valuable intermediate in multi-step synthetic pathways common in drug development.
Contribution to Drug Discovery and Development
In pharmaceutical research, intermediates like 2-Chloro-5-nitro-pyridin-4-ol are instrumental in building complex molecular scaffolds. Researchers can leverage its structure to introduce specific functionalities or to extend carbon chains, ultimately synthesizing compounds with potential therapeutic activities. For example, the transformation of the nitro group into an amine opens avenues for creating amide linkages or for further heterocyclic ring formations, both common motifs in many active pharmaceutical ingredients (APIs).
The development of targeted therapies often requires fine-tuning the chemical structure of lead compounds. The presence of multiple reactive sites on 2-Chloro-5-nitro-pyridin-4-ol allows for systematic modifications, enabling medicinal chemists to optimize a compound’s potency, selectivity, pharmacokinetic profile, and metabolic stability. This capability significantly accelerates the drug discovery pipeline.
Why Partner with a China-Based Manufacturer?
For pharmaceutical companies and research institutions, securing a consistent supply of high-quality 2-Chloro-5-nitro-pyridin-4-ol is paramount. Manufacturers in China have become significant players in the global chemical supply chain, offering competitive pricing and advanced production capabilities. Engaging with a trusted 2-Chloro-5-nitro-pyridin-4-ol supplier in China ensures access to a reliable source of this essential intermediate, backed by stringent quality control measures.
The importance of proper handling and storage cannot be overstated. Storing 2-Chloro-5-nitro-pyridin-4-ol in a cool, dry, and well-ventilated environment is critical to maintain its chemical integrity and prevent degradation. Following standard laboratory safety protocols when working with this compound is also a necessary measure.
Conclusion
2-Chloro-5-nitro-pyridin-4-ol is more than just a chemical compound; it is a key enabler of innovation in the pharmaceutical sector. Its versatile reactivity and high purity make it an indispensable tool for drug discovery and development. By partnering with experienced manufacturers like NINGBO INNO PHARMCHEM CO.,LTD., research institutions and pharmaceutical companies can secure a reliable supply of this vital intermediate, accelerating their progress towards creating life-saving medicines.
Perspectives & Insights
Chem Catalyst Pro
“Researchers can leverage its structure to introduce specific functionalities or to extend carbon chains, ultimately synthesizing compounds with potential therapeutic activities.”
Agile Thinker 7
“For example, the transformation of the nitro group into an amine opens avenues for creating amide linkages or for further heterocyclic ring formations, both common motifs in many active pharmaceutical ingredients (APIs).”
Logic Spark 24
“The development of targeted therapies often requires fine-tuning the chemical structure of lead compounds.”