Solid-phase peptide synthesis (SPPS) has revolutionized the field of peptide chemistry, enabling the efficient and scalable production of complex peptides for therapeutic and research purposes. Central to the success of SPPS is the choice of resin, which serves as the solid support for peptide chain elongation. Among the array of available resins, 2-Chlorotrityl Chloride Resin has gained significant traction due to its unique chemical properties and advantages. As a premier supplier of specialized chemical reagents, we are committed to providing researchers with the highest quality materials, including advanced resins like 2-Chlorotrityl Chloride Resin.

Understanding 2-Chlorotrityl Chloride Resin

2-Chlorotrityl Chloride (2-CTC) resin is a functionalized polystyrene resin that acts as a solid support for the first amino acid in SPPS. The '2-chloro' modification on the trityl chloride moiety influences its acid lability, offering a distinct balance compared to other trityl-based or alkoxybenzyl resins. Typically available with specific cross-linking percentages (e.g., 1% DVB) and mesh sizes (e.g., 100-200 mesh), the loading capacity, often expressed in mmol/g (e.g., 1.0-1.4 mmol/g), is a critical specification for synthesis planning. When purchasing this resin, these parameters are crucial for optimizing reaction yields and purity.

Key Advantages in Peptide Synthesis

The widespread adoption of 2-Chlorotrityl Chloride Resin in advanced peptide synthesis stems from several key advantages:

  • Milder Cleavage Conditions: The 2-CTC linker is moderately acid-labile, allowing for cleavage of the fully assembled peptide from the resin under milder acidic conditions compared to some other linkers. This is beneficial for peptides containing acid-sensitive amino acid side chains.
  • Reduced Racemization: When loading the first amino acid onto the resin, trityl-based linkers, including 2-CTC, are known to minimize racemization. This is a critical factor in ensuring the stereochemical integrity of the synthesized peptide, especially important for biologically active sequences.
  • Protection of Carboxylic Acids: The resin can also be used to attach carboxylic acids, serving as an effective protecting group reagent. This is particularly useful for synthesizing modified peptides or creating specific peptide fragments.
  • Convergent Synthesis: 2-Chlorotrityl Chloride Resin is well-suited for convergent peptide synthesis strategies, where pre-synthesized peptide fragments are coupled together.
  • Scalability: Its robustness and favorable reaction profile make it a suitable choice for both laboratory-scale research and industrial-scale peptide manufacturing. Buyers seeking bulk quantities for production will find this resin to be a reliable option.

Choosing the Right Supplier

For researchers and manufacturers in need of 2-Chlorotrityl Chloride Resin, selecting a reputable supplier is paramount. As a dedicated chemical manufacturer, we provide high-quality resins that meet stringent specifications, ensuring optimal performance in your peptide synthesis workflows. We offer competitive pricing for bulk orders and are committed to providing excellent customer support. Whether you are developing novel peptide therapeutics or conducting fundamental research, our 2-Chlorotrityl Chloride Resin is engineered for success. We encourage you to request a quote to explore how our products can enhance your synthesis projects.