The pharmaceutical industry is heavily reliant on a complex web of chemical synthesis, where specific intermediates act as crucial building blocks for Active Pharmaceutical Ingredients (APIs). 2-Methylpropanimidamide hydrochloride (CAS 22007-68-7) is one such vital compound, playing a significant role in the creation of various therapeutic agents. Understanding its application and the importance of sourcing it correctly is key for pharmaceutical manufacturers.

2-Methylpropanimidamide Hydrochloride: A Key Pharmaceutical Intermediate

This chemical, typically appearing as a white to off-white powder or crystalline solid, is characterized by its molecular formula C4H11ClN2 and a molecular weight of 122.60 g/mol. Its purity, often specified at a minimum of 97%, is a critical factor for its use in pharmaceutical synthesis, where even minor impurities can affect the efficacy, safety, and regulatory compliance of the final drug product. The physical properties, such as its melting point of 159℃, provide important parameters for process chemists during reaction design and scale-up.

Function in API Synthesis

The imidamide functional group within 2-methylpropanimidamide hydrochloride makes it a versatile synthon for constructing nitrogen-containing heterocyclic rings, which are prevalent in many drug molecules. It can participate in condensation reactions, cyclizations, and other transformations to form the core structures of APIs. For instance, it might be used in the synthesis pathways for certain antiviral, antibacterial, or cardiovascular medications, though specific applications are often proprietary.

Ensuring Quality and Reliability for Pharmaceutical Use

For pharmaceutical companies, the selection of a supplier for 2-methylpropanimidamide hydrochloride is a decision with significant implications. The following aspects are paramount:

  • Consistent High Purity: A supplier must reliably provide material meeting the specified purity levels (e.g., 97% min). Manufacturers should be able to provide detailed Certificates of Analysis (CoA) for each batch.
  • Traceability and Documentation: Robust batch tracking and comprehensive documentation are essential for regulatory compliance (e.g., GMP requirements).
  • Supply Chain Security: Pharmaceutical production schedules are often stringent. A dependable manufacturer with sufficient stock and efficient logistics, ideally with a global presence or strong export capabilities, is crucial. Sourcing from manufacturers in China can offer competitive advantages in terms of both price and availability.
  • Regulatory Compliance: Suppliers should be aware of and capable of meeting the regulatory requirements specific to pharmaceutical intermediates in target markets.

Purchasing Considerations

When looking to buy 2-methylpropanimidamide hydrochloride for pharmaceutical applications, it is advisable to:

  • Engage directly with manufacturers who can provide expert technical support.
  • Request free samples to validate product quality before placing large orders.
  • Obtain detailed quotations that include all costs, from product to delivery.
  • Look for suppliers who can demonstrate a commitment to quality and a stable manufacturing process.

By prioritizing quality, reliability, and proper supplier vetting, pharmaceutical manufacturers can ensure that 2-methylpropanimidamide hydrochloride effectively supports their API synthesis, contributing to the development of safe and effective medicines.