For procurement professionals in the pharmaceutical industry, understanding the critical intermediates used in drug synthesis is fundamental to ensuring a stable and cost-effective supply chain. 2-Pyridinecarboxaldehyde (CAS 1121-60-4) is one such compound, playing a pivotal role in the production of essential medicines.

What is 2-Pyridinecarboxaldehyde?

2-Pyridinecarboxaldehyde is an organic compound belonging to the class of pyridine derivatives. It is characterized by a pyridine ring substituted with a formyl group at the 2-position. Typically appearing as a light yellow to light brown liquid, it is sensitive to air and light, requiring careful handling and storage. Its key properties, such as a boiling point of 181°C and a density of 1.126 g/mL, are important considerations for its use in chemical processes.

Critical Applications in Pharmaceutical Synthesis:

The primary demand for 2-Pyridinecarboxaldehyde stems from its use as a key intermediate in the synthesis of two significant pharmaceutical products:

  • PAM (Pralidoxime): This compound is a vital antidote for organophosphate poisoning, acting as a cholinesterase reactivator. The production of PAM relies heavily on a consistent supply of high-purity 2-Pyridinecarboxaldehyde. Procurement teams must ensure the intermediate meets stringent quality standards to guarantee the efficacy and safety of the final drug.
  • Bisacodyl: This widely used stimulant laxative also utilizes 2-Pyridinecarboxaldehyde in its synthesis pathway. The reliability of supply for this intermediate directly impacts the availability of this common medication.

Strategic Sourcing for Procurement Managers:

Given the critical nature of these applications, procurement managers need a robust strategy for sourcing 2-Pyridinecarboxaldehyde (CAS 1121-60-4). Key considerations include:

  • Supplier Reliability: Partnering with manufacturers who have a proven track record of consistent quality and on-time delivery is essential. Look for suppliers with robust quality management systems.
  • Purity and Specifications: Ensure the supplier can consistently deliver 2-Pyridinecarboxaldehyde at the required purity levels (e.g., ≥98.0% GC) and adheres to all necessary specifications.
  • Cost-Effectiveness: Direct sourcing from manufacturers, especially those in China, often provides the most competitive pricing for bulk purchases. Obtaining multiple quotes and comparing them is a standard procurement practice.
  • Supply Chain Management: Understanding lead times, shipping logistics, and the supplier's production capacity is crucial for effective supply chain management.
  • Regulatory Compliance: Confirm that the supplier can provide necessary documentation, such as Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS), and adheres to relevant industry regulations.

As a dedicated manufacturer and supplier of 2-Pyridinecarboxaldehyde, we understand the stringent demands of the pharmaceutical industry. We are committed to providing high-purity intermediates with a focus on quality, reliability, and competitive pricing. We encourage pharmaceutical procurement managers to reach out to us to discuss their specific needs for 2-Pyridinecarboxaldehyde (CAS 1121-60-4) and explore how our capabilities can support your drug synthesis requirements.