The chemical industry continually seeks robust and versatile intermediates to drive innovation in pharmaceuticals, agrochemicals, and materials science. 2-Pyrimidinesulfonamide (CAS 142047-90-3) is a prime example of such a compound, offering a unique combination of a biologically relevant pyrimidine scaffold and a functional sulfonamide group. Its utility extends across various advanced synthetic pathways, enabling the creation of novel molecules with significant therapeutic and agricultural applications.

The synthesis of 2-Pyrimidinesulfonamide derivatives often involves sophisticated chemical methodologies. Common routes include nucleophilic substitution reactions and cross-coupling techniques, such as the Ni-catalyzed Suzuki–Miyaura reaction, which allow for the precise assembly of complex structures. For example, starting with pyrimidinyl sulfones as electrophiles, chemists can efficiently synthesize 2,4-disubstituted pyrimidines. The purity of these derivatives is critical, and optimization techniques like recrystallization, column chromatography, and high-performance liquid chromatography (HPLC) are employed to achieve the high standards required for pharmaceutical and agrochemical research.

In pharmaceutical research, 2-Pyrimidinesulfonamide serves as a foundational element for developing drugs targeting various diseases. Its derivatives have demonstrated potent anticancer activity by interfering with cancer cell proliferation and survival pathways. Furthermore, their potential as antimalarial agents against resistant strains highlights their broad therapeutic applicability. The ability to precisely functionalize this intermediate makes it invaluable for medicinal chemists aiming to create targeted therapies with improved efficacy and reduced side effects.

In the agrochemical sector, pyrimidine-sulfonamide hybrids are being explored for their herbicidal properties, particularly as inhibitors of essential plant enzymes. The chemical versatility of 2-Pyrimidinesulfonamide allows for the tailoring of compounds to target specific weed species while ensuring crop safety. This contributes to the development of more sustainable agricultural practices and effective weed management strategies.

For researchers and manufacturers in these fields, sourcing high-quality 2-Pyrimidinesulfonamide is essential. NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier of fine chemical intermediates, offering this critical compound. We provide high-purity 2-Pyrimidinesulfonamide (CAS 142047-90-3) at competitive prices, ensuring a reliable supply chain for your advanced synthetic projects. Our commitment to quality and customer satisfaction makes us an ideal partner for companies looking to innovate in the chemical sciences. If you need to buy this intermediate or are seeking a trusted supplier in China, NINGBO INNO PHARMCHEM is ready to meet your needs.

In conclusion, 2-Pyrimidinesulfonamide is a vital intermediate underpinning advanced chemical synthesis, particularly in the pharmaceutical and agrochemical industries. Its chemical versatility, coupled with advancements in synthetic methodologies, allows for the creation of novel molecules with significant societal impact. For all your requirements related to 2-Pyrimidinesulfonamide, contact NINGBO INNO PHARMCHEM CO.,LTD.