The landscape of pharmaceutical research and development is constantly evolving, driven by the need for innovative therapies and efficient synthetic routes. At the heart of this progress are key chemical intermediates, and 3-Bromo-2-hydroxypyridine (CAS: 13466-43-8) has emerged as a compound of significant interest. Its unique chemical structure and reactivity make it an indispensable building block for synthesizing a wide range of complex molecules with therapeutic potential. For pharmaceutical chemists and procurement managers, understanding its applications and how to reliably source this compound is crucial.

A Versatile Intermediate for Drug Discovery

3-Bromo-2-hydroxypyridine, characterized by a bromine atom and a hydroxyl group on a pyridine ring, offers a versatile scaffold for chemical modification. This functionality allows for diverse synthetic transformations, including palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitutions. These reactions are fundamental in constructing the intricate molecular architectures required for modern drug candidates. Researchers frequently utilize this intermediate to build pyrazolopyridine structures, which have shown promise as γ-secretase modulators, a class of compounds being investigated for various neurological disorders and cancer treatments.

Beyond its role in specific compound classes, 3-Bromo-2-hydroxypyridine is broadly applied in medicinal chemistry for generating libraries of novel compounds. Its incorporation into lead optimization programs can help fine-tune pharmacokinetic and pharmacodynamic properties, a critical step in translating a promising molecule into a viable drug. The ability to efficiently buy this intermediate in suitable quantities is therefore vital for the progress of many drug discovery projects.

Ensuring Quality and Availability: Partnering with Suppliers

The efficacy and safety of a final pharmaceutical product are heavily reliant on the quality of its starting materials and intermediates. Therefore, sourcing 3-Bromo-2-hydroxypyridine from a reputable manufacturer or supplier is non-negotiable. Look for suppliers who can guarantee high purity (often above 98% or 99% by HPLC), consistent batch-to-batch quality, and reliable supply chains. A supplier with strong technical support and transparent documentation, such as Certificates of Analysis (CoA), can significantly streamline the procurement process.

When you need to purchase this compound, consider factors like minimum order quantities, pricing for different pack sizes, and delivery timelines. Manufacturers based in China are increasingly recognized for their advanced synthesis capabilities and competitive pricing, making them attractive partners for global pharmaceutical companies. Engaging with a dedicated supplier means you can focus on your research, confident in the quality and availability of your essential building blocks.

In conclusion, 3-Bromo-2-hydroxypyridine (CAS 13466-43-8) plays a pivotal role in advancing pharmaceutical research. Its versatility as a synthetic intermediate, coupled with the availability of high-quality material from reliable manufacturers, empowers chemists to innovate and develop the next generation of life-saving medications.