The realm of organic synthesis is constantly evolving, with chemists seeking novel reagents and intermediates to build increasingly complex molecules. Among these valuable compounds, halogenated aromatics play a pivotal role due to their versatile reactivity. 3-Bromo-5-fluoroanisole (CAS 29578-39-0) is a prime example, offering a unique combination of functional groups that make it an attractive building block for a wide array of synthetic targets.

As a specialized organic intermediate, 3-Bromo-5-fluoroanisole (with the molecular formula C7H6BrFO and molecular weight 205.02) provides chemists with a platform for intricate molecular design. Its structure, featuring a methoxy group, a bromine atom, and a fluorine atom on a benzene ring, allows for diverse chemical transformations. This makes it particularly sought after in academic research and industrial synthesis, especially in sectors like pharmaceuticals and agrochemicals.

Synthetic Versatility of 3-Bromo-5-fluoroanisole

The key to 3-Bromo-5-fluoroanisole's utility lies in the reactivity of its halogen substituents. The bromine atom, being a good leaving group, is highly amenable to palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings. These reactions are fundamental in carbon-carbon bond formation, enabling the attachment of various organic fragments to the aromatic core. This allows for the precise construction of biaryls, alkynylated aromatics, and other complex structures.

The presence of the fluorine atom also imparts unique electronic properties and can influence the reactivity of the molecule. Fluorine substitution is a common strategy in medicinal chemistry to improve metabolic stability, lipophilicity, and receptor binding affinity of drug candidates. Therefore, intermediates like 3-Bromo-5-fluoroanisole are invaluable for introducing fluorine into target molecules.

Furthermore, the methoxy group can be manipulated or serve as a handle for further derivatization. For instance, it can be demethylated to a phenol, opening up additional synthetic routes. This multifaceted reactivity profile makes 3-Bromo-5-fluoroanisole a highly adaptable intermediate for custom synthesis projects.

Applications and Industry Demand

The primary driver for the demand for 3-Bromo-5-fluoroanisole is its application as a pharmaceutical intermediate. It is instrumental in the synthesis of various APIs, contributing to the development of new treatments for a multitude of medical conditions. Researchers often look to buy this compound for early-stage drug discovery and lead optimization efforts.

Beyond pharmaceuticals, the compound finds utility in the agrochemical sector for the creation of new pesticides and herbicides, as well as in material science for the development of advanced polymers and specialty chemicals where specific electronic or physical properties are desired.

Partnering with a Reliable Supplier for Your Synthesis Needs

For research scientists and procurement specialists, securing a consistent supply of high-quality 3-Bromo-5-fluoroanisole is paramount. NINGBO INNO PHARMCHEM CO.,LTD. stands as a premier manufacturer and supplier of this critical intermediate. We offer products with guaranteed purity (≥99.0%) and provide comprehensive technical data, including CAS No. 29578-39-0, to support your synthesis planning.

We understand the importance of reliable sourcing in advanced organic synthesis. Our commitment to quality control and efficient logistics ensures that you receive your materials on time and to specification. If you are looking to purchase 3-Bromo-5-fluoroanisole for your next research project or industrial application, we encourage you to contact us. NINGBO INNO PHARMCHEM CO.,LTD. is your trusted partner for sourcing critical organic building blocks, offering competitive pricing and expert support to facilitate your chemical endeavors.