In the complex tapestry of pharmaceutical research and development, specific chemical intermediates form the bedrock upon which life-saving medications are built. One such critical compound is 4-Bromo-2,6-dimethylaniline (CAS 24596-19-8). As a seasoned manufacturer of fine chemicals, NINGBO INNO PHARMCHEM CO.,LTD. understands the pivotal role this intermediate plays, particularly in the synthesis of important pharmaceuticals like Rilpivirine. This piece delves into its chemical properties, synthesis applications, and the critical considerations for sourcing this compound.

Chemical Identity and Properties of 4-Bromo-2,6-dimethylaniline

Also known by various synonyms such as 4-amino-3,5-dimethylbromobenzene, 4-Bromo-2,6-dimethylaniline is characterized by its brown crystalline appearance. With a molecular formula C8H10BrN and a molecular weight of 200.076, its density is approximately 1.4 g/cm³, and it melts in the range of 48-51 °C. A key specification is its purity, often guaranteed at ≥98.0%, which is paramount for its use in sensitive pharmaceutical synthesis pathways.

Synthesis Pathways and Applications

The primary application driving the demand for 4-Bromo-2,6-dimethylaniline is its function as a precursor in the synthesis of Rilpivirine (CAS: 500287-72-9). Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) widely used in the treatment of HIV-1 infection. The synthetic routes commonly employ 4-Bromo-2,6-dimethylaniline as a starting material, where its brominated aromatic structure is strategically modified through reactions involving acrylonitrile or acrylamide, palladium catalysts, and subsequent deprotection steps to build the complex Rilpivirine molecule. The purity of the 4-Bromo-2,6-dimethylaniline directly influences the efficiency of these reactions and the quality of the final API.

Beyond pharmaceuticals, its chemical structure suggests potential applications in the broader fine chemical industry, including roles in dye synthesis and as an intermediate for agrochemicals. Researchers constantly explore its utility in novel material science applications as well.

Sourcing and Manufacturer Considerations

For companies looking to purchase 4-Bromo-2,6-dimethylaniline, partnering with a reputable manufacturer is essential. Key factors to consider include:

  • Quality Assurance: A commitment to high purity (≥98.0%) and batch-to-batch consistency is non-negotiable for pharmaceutical applications.
  • Production Capacity: The ability to supply the required volumes, from laboratory scale to commercial quantities.
  • Technical Support: Access to technical data and support from the manufacturer can aid in process optimization.
  • Competitive Pricing: Sourcing from an efficient manufacturer, particularly one in China, can lead to significant cost savings.

Choosing a Chinese Manufacturer

When you decide to buy 4-Bromo-2,6-dimethylaniline from a Chinese supplier like NINGBO INNO PHARMCHEM CO.,LTD., you benefit from advanced manufacturing capabilities, economies of scale, and competitive pricing. We pride ourselves on providing high-quality intermediates that meet international standards. Our expertise ensures that you receive a reliable supply chain and a product that supports your demanding synthesis requirements.

We encourage pharmaceutical companies and chemical researchers to explore our offerings. To learn more about the price and availability of 4-Bromo-2,6-dimethylaniline, please reach out to our sales team. Securing high-quality intermediates from a trusted 4-Bromo-2,6-dimethylaniline supplier in China is a key step towards successful pharmaceutical development and production.