In the dynamic world of pharmaceutical research and development (R&D), access to high-quality chemical intermediates is not just a requirement, but a cornerstone of innovation and success. One such critical compound is 4-Bromophenylacetic acid, identified by its CAS number 1878-68-8. This versatile molecule plays a significant role as a building block in the synthesis of various biologically active compounds, particularly those with therapeutic potential.

Understanding the Chemical Profile of 4-Bromophenylacetic Acid

4-Bromophenylacetic acid, often described as a white to off-white crystalline powder, is a fine chemical intermediate. Its chemical structure features a phenylacetic acid backbone with a bromine substituent at the para position. This specific arrangement contributes to its reactivity and utility in complex synthetic pathways. For pharmaceutical applications, purity is paramount, and reputable suppliers typically offer this compound with a purity of 97% to 99% or higher, confirmed by techniques like HPLC. The melting point, generally around 114-117 °C, is another key indicator of its quality and consistency.

Applications in Pharmaceutical Development

The primary driver for the demand of 4-Bromophenylacetic acid in the pharmaceutical industry stems from its utility as a key intermediate:

  • Anti-inflammatory Drug Synthesis: This compound is frequently employed in the multi-step synthesis of anti-inflammatory agents. Its structure provides a scaffold that can be further modified to create molecules with targeted biological activity, helping to alleviate inflammatory responses in various conditions.
  • Drug Discovery and Lead Optimization: Researchers utilize 4-Bromophenylacetic acid in lead optimization phases, where subtle modifications to molecular structures can significantly impact efficacy, bioavailability, and safety profiles. Its availability enables the exploration of diverse chemical space.
  • API Manufacturing: For the commercial production of Active Pharmaceutical Ingredients (APIs) that incorporate this structural motif, securing a consistent supply of high-purity 4-Bromophenylacetic acid from reliable manufacturers is essential for batch-to-batch reproducibility and regulatory compliance.

Why Sourcing from Expert Manufacturers Matters

When procuring 4-Bromophenylacetic acid for pharmaceutical applications, the choice of supplier is critical. Partnering with an experienced manufacturer and supplier, especially those based in China with established expertise in fine chemical synthesis, offers several advantages:

  • Guaranteed Purity and Quality: Expert manufacturers adhere to strict quality control measures, ensuring that the 2-(4-bromophenyl)acetic acid meets stringent pharmaceutical-grade specifications. This includes rigorous testing for impurities and contaminants.
  • Cost-Effectiveness: Sourcing directly from a manufacturer can significantly reduce costs compared to intermediaries, allowing R&D budgets to be stretched further. Understanding the typical price range for this chemical is also beneficial for negotiation.
  • Supply Chain Stability: Reliable manufacturers provide assurance of a consistent and stable supply, which is crucial for maintaining uninterrupted R&D pipelines and production schedules.
  • Technical Expertise: Manufacturers often possess deep knowledge of the synthesis and handling of their products, offering valuable technical support and insights to their clients.

In conclusion, 4-Bromophenylacetic acid (CAS 1878-68-8) is a cornerstone intermediate for pharmaceutical R&D. By carefully selecting a reputable manufacturer and supplier, pharmaceutical companies can ensure access to the high-quality materials needed to drive innovation and bring life-saving treatments to market. When you need to buy this essential compound, look for suppliers who prioritize quality, reliability, and expertise.