In the intricate world of pharmaceutical manufacturing, the quality and availability of key intermediates are foundational to successful drug development and production. 4-Fluorophenylacetonitrile (CAS 459-22-3) is a prime example of such a vital chemical building block. Its unique structure as a fluorinated benzene acetonitrile compound makes it an indispensable component in the synthesis of various high-value pharmaceuticals, most notably Aprepitant.

Aprepitant, a selective neurokinin-1 receptor antagonist, plays a crucial role in managing chemotherapy-induced nausea and vomiting (CINV). The efficient synthesis of Aprepitant directly depends on the purity and reliable supply of intermediates like 4-Fluorophenylacetonitrile. As a versatile pharmaceutical intermediate, its application extends beyond antiemetics, contributing to the broader field of organic synthesis where precise molecular construction is required.

For researchers and formulators, understanding the specifications of 4-Fluorophenylacetonitrile is key. A typical high-grade product will feature an assay of 98.0% or higher, presented as a clear colorless to light yellow liquid. Availability in standard packaging, such as 200kg drums, facilitates bulk purchasing for industrial applications. When seeking to buy this compound, it is advisable to partner with a chemical manufacturer that can provide consistent quality and technical support. Sourcing from a reputable supplier, particularly those in regions like China known for their chemical manufacturing prowess, often presents opportunities for competitive pricing.

The journey from intermediate to finished pharmaceutical product requires a robust supply chain. Companies seeking to secure their supply of 4-Fluorophenylacetonitrile should investigate manufacturers’ adherence to quality management systems and their capacity to meet demand. Engaging with a knowledgeable manufacturer ensures access to essential documentation like SDS and TDS, facilitating regulatory compliance and safe handling. For B2B clients, the ease of inquiry and purchase process, often supported by online platforms, further streamlines procurement.

In essence, 4-Fluorophenylacetonitrile is more than just a chemical compound; it is an enabler of critical therapeutic advancements. By prioritizing reliable sourcing from qualified manufacturers and suppliers, the pharmaceutical industry can continue to innovate and deliver life-changing treatments effectively and affordably.