The development of effective treatments for allergies and inflammatory conditions relies heavily on advanced pharmaceutical intermediates. Among these, 4-Hydroxypiperidine (CAS: 5382-16-1) stands out for its pivotal role in the synthesis of widely used antihistamines such as Bepotastine besilate and Rupatidine. As a chemical building block, its quality and availability directly impact the production of these vital medications. Pharmaceutical scientists and procurement managers consistently seek reliable sources for this compound.

4-Hydroxypiperidine: A Cornerstone for Antihistamines
4-Hydroxypiperidine, a white crystalline powder, is a derivative of piperidine that possesses a hydroxyl group at the 4-position. This specific functionalization makes it an ideal starting material for constructing the complex molecular frameworks of many second-generation antihistamines. These drugs are designed to block the action of histamine, a compound released during allergic reactions, thereby alleviating symptoms like itching, sneezing, and nasal congestion. The precision required in synthesizing these medications means that the purity and chemical integrity of intermediates like 4-Hydroxypiperidine are non-negotiable.

Applications in Drug Manufacturing
The primary application of 4-Hydroxypiperidine in the pharmaceutical industry is as a key intermediate in the synthesis of Bepotastine besilate and Rupatidine. Bepotastine besilate is a potent H1-receptor antagonist used to treat allergic rhinitis and urticaria. Rupatidine is also a selective H1-receptor antagonist with additional antiplatelet-activating factor (PAF) activity, making it effective for allergic conditions. The synthesis pathways for these drugs often involve coupling 4-Hydroxypiperidine with other chemical moieties, highlighting its importance as a versatile building block.

Sourcing Strategies for Pharmaceutical Intermediates
For companies involved in the manufacturing of these antihistamines, securing a consistent and high-quality supply of 4-Hydroxypiperidine is a strategic priority. When looking to purchase this intermediate, it is crucial to identify manufacturers and suppliers who can guarantee:

  • High Purity: Ensuring the intermediate meets stringent pharmaceutical specifications (e.g., ≥98.0% assay) is vital for downstream synthesis and final product efficacy.
  • Scalability: The ability of a supplier to meet demand from R&D quantities to commercial bulk orders is essential for growth.
  • Regulatory Documentation: Availability of Certificates of Analysis (CoA), Material Safety Data Sheets (MSDS), and potentially Drug Master Files (DMFs) simplifies compliance.
  • Competitive Pricing: Sourcing from efficient manufacturers, often located in regions like China, can lead to significant cost advantages.

As a leading chemical manufacturer and supplier, we understand the critical nature of these requirements. We are dedicated to providing high-purity 4-Hydroxypiperidine, backed by robust quality control and a commitment to reliable delivery. Our aim is to be your trusted partner in the pharmaceutical supply chain, ensuring you have the essential materials needed to bring life-changing medications to market.

By focusing on the quality and availability of intermediates like 4-Hydroxypiperidine, the pharmaceutical industry can continue to innovate and provide effective treatments for widespread health conditions.