The pharmaceutical industry relies on a complex network of chemical synthesis and manufacturing processes, where specific intermediates act as crucial building blocks for life-saving and life-improving drugs. Among these, 4-Sulfonamide-phenylhydrazine hydrochloride (CAS: 27918-19-0) holds a significant position, primarily as a key intermediate in the production of Celecoxib, a widely used anti-inflammatory medication. This article delves into the role and importance of this compound in modern pharmaceutical and chemical synthesis.

A Cornerstone for Celecoxib Synthesis

Celecoxib, a selective COX-2 inhibitor, is prescribed for conditions such as arthritis and acute pain. The synthesis of this complex molecule necessitates precise chemical reactions, and 4-Sulfonamide-phenylhydrazine hydrochloride is a vital precursor that enables the construction of the Celecoxib molecular framework. Its specific chemical structure and reactivity make it an ideal starting material for forming the core pyrazole ring system of Celecoxib.

Quality and Purity: Non-Negotiable Aspects

For R&D scientists and production managers, the quality of 4-Sulfonamide-phenylhydrazine hydrochloride is paramount. A high assay, typically above 98.0% via HPLC, is essential to ensure efficient reaction yields and to minimize the formation of impurities. Impurities in intermediates can carry through to the final API, potentially affecting its efficacy, safety profile, and regulatory compliance. Therefore, sourcing this compound from reputable manufacturers, such as those in China known for their chemical synthesis expertise, is a strategic decision. NINGBO INNO PHARMCHEM CO.,LTD., for instance, focuses on providing high-purity intermediates like this, often available in standard packaging like 25 kg drums.

Beyond Celecoxib: Broader Chemical Applications

While its primary application is in Celecoxib manufacturing, phenylhydrazine derivatives like 4-Sulfonamide-phenylhydrazine hydrochloride can also serve as versatile building blocks in broader organic chemistry. They are utilized in the synthesis of various heterocyclic compounds, dyes, and agrochemicals, showcasing the foundational role such intermediates play across different sectors of the chemical industry. Researchers looking to buy these types of compounds can find extensive options from global suppliers.

Choosing the Right Partner

When selecting a supplier for 4-Sulfonamide-phenylhydrazine hydrochloride, it’s crucial to assess their commitment to quality control, production capacity, and customer service. Establishing a strong relationship with a manufacturer that understands the demands of the pharmaceutical industry ensures a reliable supply chain, allowing companies to focus on innovation and production.