For research scientists and formulation chemists, understanding the precise role of chemical intermediates is fundamental to successful drug development. 5-Bromo-2-chloro-4'-ethoxydiphenylmethane (CAS: 461432-23-5) stands out as a crucial building block, particularly in the synthesis of modern pharmaceuticals like Dapagliflozin. This article delves into its chemical significance and the importance of reliable sourcing for research and development endeavors.

Chemical Profile and Significance

5-Bromo-2-chloro-4'-ethoxydiphenylmethane is characterized by its unique structural features, which make it an ideal precursor for complex organic syntheses. The presence of bromine, chlorine, and ethoxy groups on specific positions of the diphenylmethane core allows for targeted chemical transformations. Its molecular formula, C15H14BrClO, and molecular weight of approximately 325.63 g/mol, are critical parameters for stoichiometric calculations in reaction design. The product's typical appearance as a white to off-white solid with a low melting point further aids in its handling and processing in laboratory settings.

Key Application: Dapagliflozin Synthesis

The most prominent application of 5-Bromo-2-chloro-4'-ethoxydiphenylmethane is its use as a direct intermediate in the manufacturing pathway of Dapagliflozin. Dapagliflozin is a highly selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), used globally to manage type 2 diabetes mellitus. The synthesis of such a complex API requires highly specific and pure intermediates to ensure the final product meets pharmacopoeial standards. The structural integrity and purity of this intermediate directly influence the yield and quality of the final Dapagliflozin API. Researchers often search for specific CAS numbers like 461432-23-5 when looking to buy these critical components.

Manufacturing and Sourcing Considerations for Scientists

For R&D scientists, identifying a reliable supplier of 5-Bromo-2-chloro-4'-ethoxydiphenylmethane is as important as the reaction chemistry itself. When sourcing this chemical, consider:

  • Purity Levels: High purity is non-negotiable. Minor impurities in intermediates can lead to side reactions, reduced yields, and the formation of undesirable by-products in the final API. Manufacturers in China often provide purity levels of 98% or higher.
  • Batch-to-Batch Consistency: Uniformity in product quality across different batches is essential for reproducible research and scalable manufacturing.
  • Technical Documentation: Access to detailed analytical data, such as NMR spectra, HPLC chromatograms, and MS data, is vital for verifying identity and purity. This information is crucial for scientists evaluating the suitability of the intermediate.
  • Availability and Lead Times: Understanding supplier lead times helps in project planning. Companies often need to secure supply agreements for critical intermediates to avoid research delays.

Finding Competitive Prices for Your Research Needs

While quality is paramount, budgetary constraints are a reality in research. Identifying suppliers who can offer competitive prices for 5-Bromo-2-chloro-4'-ethoxydiphenylmethane without compromising quality is key. Engaging directly with manufacturers or their authorized distributors in China can often provide better pricing structures and access to bulk purchase discounts, especially when planning for larger experimental studies or pilot-scale synthesis.

In conclusion, 5-Bromo-2-chloro-4'-ethoxydiphenylmethane is more than just a chemical compound; it is an enabler of critical therapeutic advancements. By understanding its role and prioritizing reliable, high-quality sourcing from experienced manufacturers, pharmaceutical researchers and procurement professionals can accelerate their drug development pipelines effectively.