In the landscape of chemical synthesis, certain molecules serve as foundational elements, enabling the creation of a vast array of complex compounds. 5-Bromonaphthalen-1-amine (CAS 4766-33-0) is one such compound, highly valued for its dual functionality and its role as a key intermediate in pharmaceutical and fine chemical manufacturing. For R&D scientists and procurement specialists, understanding its utility and how to source it effectively is crucial for project success.

Understanding the Chemical Profile

5-Bromonaphthalen-1-amine is an aromatic organic compound featuring a naphthalene core substituted with a bromine atom and an amino group. This specific arrangement of functional groups provides chemists with two distinct points for chemical modification. The bromine atom, attached to the aromatic ring, is an excellent leaving group and a prime site for palladium-catalyzed cross-coupling reactions, enabling the formation of new C-C bonds. This is invaluable for building molecular complexity. Simultaneously, the amine group can undergo a variety of transformations, including acylation, alkylation, and participation in condensation reactions. Typically supplied as a solid, often in dark brown shades, with a purity of 97% or higher, this compound is a staple in many synthetic laboratories.

Key Applications Driving Demand

  • Pharmaceutical Manufacturing: A primary application for 5-Bromonaphthalen-1-amine is its use as an intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its structure can be integral to the final drug molecule or modified through synthetic routes to introduce specific pharmacological properties. Procurement managers often seek reliable suppliers for this critical input.
  • Advanced Organic Synthesis: The compound is widely employed as a versatile building block in academic and industrial research settings. Its reactivity allows for the construction of diverse heterocyclic systems, complex polycyclic aromatic compounds, and other specialty organic molecules.
  • Material Science Exploration: The inherent photophysical properties of naphthalene derivatives also make 5-Bromonaphthalen-1-amine a subject of interest in material science research, potentially for developing organic electronic materials or fluorescent probes.
  • Custom Synthesis Projects: Given its versatile nature, it is also a frequently requested starting material for custom synthesis projects, where specific derivatives or more complex molecules are tailored to unique research requirements.

Navigating the Procurement Process

When you need to buy 5-Bromonaphthalen-1-amine, your primary goal is to secure a consistent and high-quality supply. This involves identifying manufacturers and suppliers who specialize in fine chemicals and organic intermediates. Key factors to consider when evaluating a supplier include:

  • Purity Levels: Always verify that the product meets your required purity specifications, typically 97% or higher for demanding applications.
  • Supplier Reputation: Look for established manufacturers with a strong track record in quality control and customer service. Requesting product samples and Certificates of Analysis (CoA) is a standard practice.
  • Pricing and Volume: Compare pricing from multiple sources, especially for larger quantities. Negotiate terms that reflect your purchasing volume and long-term needs.
  • Global Availability: Many leading manufacturers are located in regions like China, offering competitive pricing and large-scale production capabilities. Understanding lead times and logistics is crucial for maintaining your project timelines.

In conclusion, 5-Bromonaphthalen-1-amine (CAS 4766-33-0) is an indispensable tool for modern chemists. By understanding its chemical properties, applications, and by strategically sourcing it from reliable global manufacturers, industries can ensure the efficient progression of their research and production endeavors.