The development of effective antiviral therapies is a cornerstone of modern medicine. Central to this endeavor is the intricate process of synthesizing complex pharmaceutical molecules, which often relies on the availability of specialized chemical intermediates. Among these, 6-(Benzyloxy)-9-[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]-9H-purine-2-amine, known by its CAS number 204845-95-4, plays a pivotal role as a key intermediate, particularly in the synthesis of Entecavir. This article explores its significance and the considerations for sourcing this critical compound.

Entecavir is a potent nucleoside analog reverse transcriptase inhibitor used in the treatment of chronic hepatitis B infection. The synthesis of such a complex molecule requires a carefully orchestrated series of chemical reactions, where each intermediate contributes specific structural elements. CAS 204845-95-4, with its distinctive purine and cyclopentyl framework featuring multiple benzyloxy groups, serves as an advanced building block in the multi-step synthesis of Entecavir.

The precise stereochemistry and functional groups present in this intermediate are crucial for its reactivity and for dictating the correct orientation of atoms in the final drug molecule. Pharmaceutical chemists rely on intermediates like 6-(Benzyloxy)-9-[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]-9H-purine-2-amine to efficiently construct the target API. The quality and purity of this intermediate, typically 99% or higher, directly influence the overall yield and purity of the Entecavir API.

For researchers and manufacturers looking to buy CAS 204845-95-4, partnering with reliable chemical suppliers is essential. Companies specializing in pharmaceutical intermediates, particularly those in China, offer this compound. It is important to vet these suppliers thoroughly, ensuring they can consistently deliver high-quality materials suitable for GMP (Good Manufacturing Practice) environments if required for later stages of drug development.

In essence, understanding the role of intermediates like CAS 204845-95-4 is vital for anyone involved in pharmaceutical synthesis. Its specific structure and high purity make it an indispensable component for producing advanced antiviral medications. When you need to source this crucial Entecavir intermediate, engaging with experienced chemical manufacturers and suppliers will ensure the success of your synthesis projects.