In the intricate world of pharmaceutical research and development, the availability of high-quality building blocks is fundamental to scientific progress. 6-Chloronicotinaldehyde, identified by CAS number 23100-12-1, is one such indispensable compound. This pyridine derivative, often sourced from specialized chemical manufacturers, plays a pivotal role as an intermediate in the synthesis of a wide array of Active Pharmaceutical Ingredients (APIs). Understanding its chemical properties, applications, and how to procure it effectively is crucial for R&D scientists and formulation chemists.

Chemical Profile and Significance

6-Chloronicotinaldehyde is a heterocyclic organic compound featuring a pyridine ring with a chlorine substituent and an aldehyde functional group. Its structure (C6H4ClNO) lends itself to diverse chemical transformations. Typically presenting as a white to off-white crystalline powder, it possesses a melting point in the range of 77-81°C. The aldehyde moiety is particularly reactive, allowing it to participate in numerous nucleophilic addition and condensation reactions, which are foundational steps in synthesizing complex pharmaceutical molecules.

Applications in API Synthesis

The primary utility of 6-Chloronicotinaldehyde lies in its function as a key intermediate for pharmaceuticals. It is instrumental in constructing the core structures of various drugs, including potential treatments for a range of diseases. For instance, its pyridine core is a common motif in many biologically active compounds. R&D scientists often seek this compound for:

  • Introducing a functionalized pyridine ring: The chlorine and aldehyde groups provide handles for further chemical modifications.
  • Building heterocyclic systems: It can be used to form more complex fused ring systems prevalent in drug design.
  • Screening for new drug candidates: As a versatile building block, it enables the creation of chemical libraries for drug discovery efforts.

Sourcing and Quality Control

For scientists and researchers, the quality of intermediates like 6-Chloronicotinaldehyde directly impacts the success of their synthesis. Purity, as verified by analytical methods such as HPLC or GC, is paramount. Reliable manufacturers, often based in regions like China known for their chemical production capacity, are key partners. When looking to buy 6-Chloronicotinaldehyde, R&D professionals should prioritize suppliers who offer:

  • High purity (≥96.0%): To ensure predictable and reproducible reaction outcomes.
  • Detailed product specifications: Including molecular weight, melting point, and solubility.
  • Consistent batch-to-batch quality: Essential for scaling up reactions from lab to pilot scale.
  • Responsive customer service and technical support: To assist with inquiries and potential custom synthesis needs.

By carefully selecting a supplier for 6-Chloronicotinaldehyde, pharmaceutical researchers can ensure they have access to the high-quality materials needed to drive innovation and bring new therapeutic agents to market. Inquiring about pricing and availability from reputable manufacturers is the first step towards securing this vital chemical building block.