In the ever-evolving landscape of chemical synthesis, specific molecular scaffolds and reactive intermediates play pivotal roles in advancing scientific discovery. 7-Bromo-1,2,3,4-tetrahydrocyclopenta[b]indole, bearing the CAS number 164736-47-4, is one such compound that merits attention from both research scientists and procurement professionals. Its unique structure and reactivity make it a sought-after building block in various advanced chemical applications.

Structural Significance and Reactivity

This indole derivative (C11H10BrN) combines the aromaticity of the indole system with the saturated flexibility of a fused cyclopentane ring. The bromine atom at the 7-position is particularly significant, acting as a versatile functional handle. This bromine can readily participate in a wide array of palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, enabling the facile introduction of carbon-carbon and carbon-heteroatom bonds. This capability is fundamental for constructing complex molecular architectures relevant to pharmaceuticals, agrochemicals, and advanced materials.

Market Trends and Availability for Researchers

The demand for specialized heterocyclic compounds like 7-Bromo-1,2,3,4-tetrahydrocyclopenta[b]indole is driven by ongoing research in drug discovery and materials science. As such, reliable sourcing channels are critical. Researchers looking to buy this intermediate will typically find it offered by chemical suppliers and manufacturers, often with specified purities (commonly 95% or 98%). The availability from a diverse range of global suppliers, including those based in China, ensures competitive pricing and accessibility.

For procurement managers, understanding the market dynamics is key. Factors influencing the price and availability include the complexity of synthesis, the cost of raw materials, and the scale of production. Engaging with manufacturers directly can often lead to better pricing and a more secure supply chain, especially for bulk purchases or custom synthesis projects.

Applications Driving Demand

The primary applications for 7-Bromo-1,2,3,4-tetrahydrocyclopenta[b]indole include:

  • Pharmaceutical Intermediates: Its structure is found in or is a precursor to various biologically active molecules.
  • Organic Synthesis: A versatile building block for creating diverse chemical libraries and complex target molecules.
  • Academic Research: Used in studies exploring new synthetic methodologies and the development of novel compounds.

Choosing a Supplier

When it comes to procuring 7-Bromo-1,2,3,4-tetrahydrocyclopenta[b]indole, the choice of supplier is paramount. A reputable manufacturer will offer not only competitive pricing but also guaranteed purity, comprehensive Certificates of Analysis (CoA), and responsive customer service. Exploring options from manufacturers in China can be particularly advantageous due to their production capacities and cost structures. Researchers and procurement specialists should always inquire about batch-to-batch consistency and the availability of technical data to ensure the compound meets their stringent requirements.

In conclusion, 7-Bromo-1,2,3,4-tetrahydrocyclopenta[b]indole stands out as a significant intermediate in modern chemical synthesis. Its versatile reactivity and widespread applications underscore its importance in research and development, making it a compound that every procurement manager and synthetic chemist should be familiar with.