In the intricate world of pharmaceutical manufacturing, the selection and sourcing of high-quality intermediates are foundational to success. One such critical compound is 7-Methoxy-1-naphthylacetonitrile, identified by its CAS number 138113-08-3. This aromatic nitrile is not just another chemical; it serves as a vital precursor, most notably in the synthesis of Agomelatine, a widely prescribed antidepressant. For R&D scientists and formulation chemists, understanding the chemical significance and reliable sourcing options for this intermediate is key.

Chemical Identity and Properties

7-Methoxy-1-naphthylacetonitrile is characterized by its molecular formula C13H11NO and a molecular weight of approximately 197.23 g/mol. Its structure features a naphthalene ring system substituted with a methoxy group and an acetonitrile moiety. This specific arrangement of functional groups makes it an ideal synthon for building more complex molecular architectures. Typically appearing as a white solid, its melting point often falls within the range of 81-83°C, indicating its stable solid form at room temperature. This physical state is advantageous for handling, storage, and transportation, simplifying the procurement process for manufacturers.

The Agomelatine Connection

The primary driver for the demand of 7-Methoxy-1-naphthylacetonitrile is its indispensable role in the production pathway of Agomelatine. Agomelatine is a melatonergic antidepressant that acts on both MT1 and MT2 melatonin receptors and also blocks serotonin 5-HT2C receptors. The synthesis of Agomelatine involves several steps, where 7-Methoxy-1-naphthylacetonitrile provides the core naphthylacetonitrile structure, which is then further modified. The purity of the 7-Methoxy-1-naphthylacetonitrile used directly impacts the yield and purity of the final Agomelatine API. Therefore, pharmaceutical companies actively seek out manufacturers who can supply this intermediate with exceptional purity, often exceeding 98%.

Beyond Agomelatine: Broader Applications

While its role in Agomelatine synthesis is prominent, 7-Methoxy-1-naphthylacetonitrile's chemical structure also lends itself to other applications in fine chemical synthesis. As a versatile intermediate, it can be employed in the research and development of novel compounds, potentially for other therapeutic areas or as components in advanced materials. Its reactivity allows for various chemical transformations, making it a valuable tool for synthetic chemists exploring new molecular entities. For researchers looking to buy this compound for exploratory synthesis, partnering with a dependable supplier is essential.

Sourcing Strategies for Buyers

When procurement professionals or researchers need to purchase 7-Methoxy-1-naphthylacetonitrile, several sourcing strategies are employed. Working directly with established chemical manufacturers in regions like China, known for their robust chemical production capabilities, offers significant advantages. These manufacturers can often provide competitive pricing and ensure a stable supply. For example, a buyer might inquire about the '7-Methoxy-1-naphthylacetonitrile price in China' to gauge market rates and identify key suppliers. Understanding the supply ability, quality control measures, and delivery terms from a manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. is crucial for establishing a long-term, reliable partnership.

In conclusion, 7-Methoxy-1-naphthylacetonitrile (CAS 138113-08-3) is a cornerstone intermediate in modern pharmaceutical synthesis, particularly for Agomelatine. Its chemical structure and the stringent purity requirements for its applications underscore the importance of sourcing it from reputable manufacturers who can guarantee quality and consistency. As the demand for effective pharmaceutical agents continues, intermediates like this will remain critical components of the global chemical supply chain.