For research scientists and product formulators in the pharmaceutical industry, the choice and quality of chemical intermediates are foundational to successful drug development and manufacturing. 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride, identified by its CAS number 762240-92-6, stands out as a pivotal component in the synthesis of Sitagliptin. Understanding its chemical characteristics and sourcing it reliably is crucial for optimizing the production of this vital antidiabetic drug.

As a heterocyclic compound, 762240-92-6 possesses a specific molecular structure that is essential for its role in the multi-step synthesis of Sitagliptin. Its trifluoromethyl group and triazolo[4,3-a]pyrazine core contribute significantly to the final drug's pharmacological profile. The high purity of this intermediate, typically above 99.0% as determined by HPLC, is non-negotiable. Impurities in this stage can lead to side reactions, reduced yields, and potentially the formation of undesirable byproducts, which can complicate purification processes and affect the safety and efficacy of the final Sitagliptin API. Therefore, when R&D scientists evaluate suppliers, the consistency and reliability of purity data are key considerations.

The physical form of this intermediate, a white powder, also plays a role in laboratory and industrial settings. Its handling characteristics, solubility in common organic solvents (like DMSO and methanol, often reported as slightly soluble), and melting point (236-246°C) are important parameters for process chemists to consider during reaction design and scale-up. These properties can influence reaction kinetics, solvent choice, and crystallization procedures.

For those looking to purchase this Sitagliptin intermediate, engaging with a manufacturer that provides detailed technical specifications and robust quality control is essential. Understanding the molecular formula (C6H8ClF3N4) and molecular weight (228.60) is standard, but information regarding moisture content (typically ≤0.5%) and storage conditions (cool, ventilated place) also contributes to maintaining product integrity.

The global demand for Sitagliptin means that a consistent and reliable supply of intermediates like 762240-92-6 is critical. Companies that specialize in the manufacture of such key pharmaceutical intermediates, particularly those based in regions known for chemical production like China, can offer significant advantages in terms of cost-effectiveness and availability. When chemists and R&D professionals require this compound for their projects, they seek partners who can deliver not just the chemical itself, but also the assurance of quality and continuity needed for their demanding research and development pipelines.