Ancitabine Hydrochloride (CAS 10212-25-6), often referred to as Cyclocytidine or Cyclo-C, is a crucial pharmaceutical intermediate renowned for its potent antineoplastic properties. Its primary significance lies in its application within the medical field, specifically in the treatment of certain types of leukemia. For researchers and manufacturers involved in developing or producing life-saving treatments, understanding the role and sourcing of Ancitabine HCl is paramount.

Mechanism of Action in Leukemia Treatment
Ancitabine Hydrochloride is a nucleoside analog, meaning it structurally mimics natural nucleosides found in DNA and RNA. When introduced into the body, it can be incorporated into the genetic material of rapidly dividing cells, such as cancer cells. However, due to the altered sugar moiety (arabinose instead of ribose), this incorporation disrupts the normal processes of DNA replication and RNA transcription. This disruption inhibits the function of essential enzymes like DNA polymerase, ultimately leading to cell death. This mechanism makes Ancitabine HCl an effective agent against aggressive cancers like acute leukemia and meningeal leukemia.

Therapeutic Applications and Beyond
The primary clinical application of Ancitabine Hydrochloride is its use as an active pharmaceutical ingredient (API) or a key intermediate in the synthesis of drugs for treating acute leukemia. Its efficacy in targeting rapidly proliferating cancer cells makes it a valuable component in chemotherapy regimens. Furthermore, it has found utility in the preparation of certain ophthalmic solutions, showcasing its therapeutic versatility. For those looking to 'buy Ancitabine HCl' for these applications, sourcing from reliable manufacturers is essential.

Sourcing Ancitabine Hydrochloride: A Procurement Perspective
Procuring Ancitabine Hydrochloride, especially for pharmaceutical manufacturing, requires a diligent approach. Buyers often look for 'Ancitabine HCl suppliers' or 'Ancitabine HCl wholesale' to secure bulk quantities. Key considerations include:

  • Purity and Quality: As a pharmaceutical intermediate, high purity (typically 98%+) and consistent quality are non-negotiable. Always verify the CoA.
  • Manufacturer Reliability: Partnering with a reputable 'Ancitabine HCl manufacturer' ensures stable supply and adherence to quality standards.
  • Pricing: Competitive 'Ancitabine HCl price' is important, especially for large-scale production. Direct sourcing from manufacturers often provides better value.
  • Regulatory Compliance: Understanding the CAS number (10212-25-6) and any associated regulatory requirements is vital for smooth import and use.

Companies specializing in pharmaceutical intermediates, such as NINGBO INNO PHARMCHEM CO.,LTD., play a crucial role in connecting global buyers with trusted manufacturers. Their expertise helps in navigating the complexities of international sourcing and ensuring the acquisition of high-quality Ancitabine Hydrochloride for critical medical applications.

In conclusion, Ancitabine Hydrochloride is more than just a chemical compound; it is a vital tool in the fight against leukemia. Its effectiveness and role as a pharmaceutical intermediate underscore the importance of sourcing it responsibly and reliably from qualified manufacturers.