Magnetic Resonance Imaging (MRI) has revolutionized medical diagnostics, offering unparalleled soft-tissue contrast without the use of ionizing radiation. Central to many advanced MRI procedures is the use of contrast agents, which enhance the visibility of specific tissues and pathologies. Among the key components enabling the efficacy and safety of these agents is DOTA, chemically known as 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (CAS 60239-18-1).

DOTA is a macrocyclic chelating agent, celebrated for its remarkable ability to form highly stable complexes with various metal ions, particularly paramagnetic ions like Gadolinium (Gd3+). This robust complexation is crucial for MRI contrast agents, where the stability of the metal-Gd bond prevents the release of free Gd3+ ions, which can be toxic. The macrocyclic structure of DOTA offers a cage-like environment that effectively encapsulates the metal ion, providing superior thermodynamic and kinetic stability compared to linear chelators like DTPA. This enhanced stability translates directly into improved safety profiles for patients undergoing MRI scans.

As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides high-purity DOTA that is essential for the formulation of next-generation MRI contrast agents. Our commitment to quality ensures that our DOTA meets the stringent specifications required for pharmaceutical applications. If you are looking to buy DOTA for your MRI agent development, our competitive pricing and stable supply chain from China make us an ideal partner. We understand the critical nature of these intermediates and strive to be a reliable source for pharmaceutical companies worldwide.

The chemical properties of DOTA, including its molecular formula C16H28N4O8 and molecular weight of 404.42, underpin its effectiveness. Its white solid appearance is indicative of its high purity. By choosing NINGBO INNO PHARMCHEM as your DOTA supplier, you are investing in quality, reliability, and innovation for your diagnostic imaging solutions. We invite you to contact us to learn more about our DOTA products and how we can support your manufacturing needs.