Medicinal chemistry is a field driven by innovation, often requiring specialized building blocks to construct novel drug candidates. Ethyl N-Boc-piperidine-4-carboxylate (CAS: 142851-03-4) has emerged as a significant intermediate in this domain, valued for its versatile structure and strategic Boc protection. As a reliable manufacturer and supplier, we understand the importance of providing high-quality intermediates that empower medicinal chemists. This article delves into the compound's role, synthesis, and applications.

Understanding the Chemical Structure and Properties

Ethyl N-Boc-piperidine-4-carboxylate features a piperidine core, a common heterocyclic motif found in many biologically active molecules. The ethyl ester at the 4-position provides a handle for further modifications, while the Boc group on the nitrogen atom serves as a protecting group, allowing for controlled synthetic transformations. Typically, this compound is supplied with a purity of 97% GC, ensuring its suitability for sensitive medicinal chemistry projects. Its physical form as a light yellow viscous liquid facilitates handling and dissolution in common organic solvents.

Key Applications in Medicinal Chemistry

The utility of Ethyl N-Boc-piperidine-4-carboxylate spans several critical areas in drug discovery:

  • CNS Drug Development: Its role in synthesizing sodium channel blockers makes it relevant for developing treatments for neurological disorders. Modulating ion channels is a key strategy in addressing conditions like stroke and neuropathic pain.
  • Anti-inflammatory Agents: The intermediate is used in the preparation of TACE inhibitors, which are investigated for their potential to treat a range of inflammatory diseases by controlling cytokine signaling.
  • Scaffold for Diverse APIs: Beyond these specific applications, the functionalized piperidine ring serves as a valuable scaffold for constructing a wide array of Active Pharmaceutical Ingredients (APIs) with diverse pharmacological activities.

Sourcing High-Quality Intermediates

For medicinal chemists and procurement specialists, securing a dependable supply of Ethyl N-Boc-piperidine-4-carboxylate is crucial. As a leading manufacturer and supplier based in China, we are dedicated to providing this essential intermediate with the highest purity and consistency. Our expertise in custom synthesis and strict quality control measures ensure that your research is supported by reliable materials. If you are looking to buy this compound, consider our capabilities for bulk orders and research quantities. We offer competitive pricing and a commitment to excellence as your trusted supplier.

Engage with us to discuss your specific requirements for Ethyl N-Boc-piperidine-4-carboxylate and discover how our high-quality intermediates can accelerate your drug discovery programs.