Fmoc-D-Glu(OtBu)-OH (CAS 104091-08-9) is more than just a simple amino acid derivative; it is a sophisticated building block essential for intricate chemical synthesis, particularly in areas demanding high precision and specificity. Its structure is tailored for modern synthetic methodologies, making it a sought-after intermediate by chemists worldwide.

The core utility of Fmoc-D-Glu(OtBu)-OH lies in its application in Solid-Phase Peptide Synthesis (SPPS). The N-alpha Fmoc protection is standard for sequential amino acid addition, allowing chemists to build peptide chains step-by-step on a solid support. The tert-butyl ester on the gamma-carboxyl is crucial for managing the reactivity of the glutamic acid side chain. This protection strategy ensures that during the Fmoc deprotection step (typically using piperidine), the gamma-carboxyl remains intact, preventing premature side reactions. When researchers buy this compound, they are investing in controlled and predictable synthesis outcomes.

Beyond SPPS, Fmoc-D-Glu(OtBu)-OH serves as a valuable starting material or intermediate in the synthesis of peptidomimetics, modified peptides, and complex organic molecules. Its chirality (D-configuration) is often critical for the biological activity of the final product, making the quality and stereochemical purity of the purchased material paramount. Any chemist looking to procure this from a manufacturer will prioritize suppliers who can guarantee enantiomeric purity.

The solubility characteristics of Fmoc-D-Glu(OtBu)-OH are also noteworthy. It is soluble in common organic solvents used in synthesis, such as DMF, DCM, and Ethyl Acetate, which facilitates its incorporation into reaction mixtures. For those engaged in drug discovery or fine chemical synthesis, sourcing this from a reliable supplier, especially one with a strong presence in China, can offer both quality and cost advantages. Understanding the price points for different quantities will aid in budgeting.

The versatility of Fmoc-D-Glu(OtBu)-OH makes it a staple in the laboratories of organic chemists, medicinal chemists, and biochemists. Its role in constructing complex biomolecules underscores its importance in advancing scientific research and developing new technologies and therapies. Ensuring a consistent and high-quality supply chain for this intermediate is a key consideration for any lab focused on cutting-edge synthesis.