L-4-Nitrophenylalanine methyl ester hydrochloride (CAS 17193-40-7) stands as a pivotal compound within the pharmaceutical industry, primarily recognized for its indispensable role as an intermediate in the synthesis of Zolmitriptan. Zolmitriptan is a widely prescribed medication belonging to the triptan class, effectively used for the acute treatment of migraines, with or without aura. The synthesis of such a targeted therapeutic agent requires high-purity chemical building blocks, and this nitro-substituted phenylalanine derivative fulfills that critical need.

The chemical structure of L-4-Nitrophenylalanine methyl ester hydrochloride, with its nitro group and methyl ester functionality, provides the necessary reactivity and specific structural features required for the complex, multi-step synthesis pathways leading to Zolmitriptan. Researchers and manufacturers rely on this intermediate to ensure the correct stereochemistry and chemical integrity of the final API, which is paramount for therapeutic efficacy and patient safety. Its precise molecular formula, C10H13ClN2O4, and consistent physical properties, such as its typical yellow to off-white powder appearance, are key indicators of its quality.

For pharmaceutical companies looking to manufacture or source Zolmitriptan, securing a reliable supply of L-4-Nitrophenylalanine methyl ester hydrochloride is essential. This involves partnering with manufacturers and suppliers who can guarantee high purity levels (typically ≥98.5% by HPLC) and consistent product quality. Many leading pharmaceutical manufacturers globally source this intermediate from experienced suppliers in China, known for their robust chemical manufacturing capabilities and competitive pricing. When you aim to buy this crucial intermediate, due diligence in selecting a supplier that offers comprehensive documentation, including COAs and SDS, is highly recommended.

The demand for effective migraine treatments continues to grow, directly fueling the market for key intermediates like L-4-Nitrophenylalanine methyl ester hydrochloride. Its specialized application in Zolmitriptan synthesis underscores its importance in modern medicinal chemistry. By ensuring a stable and high-quality supply of this compound, manufacturers play a direct role in making effective migraine therapies accessible to patients worldwide. If your research or production requires this vital pharmaceutical intermediate, consider engaging with established suppliers who can meet your stringent quality and quantity requirements.