Methyl 2-aminonicotinate (CAS 14667-47-1) stands as a vital intermediate in the sophisticated landscape of pharmaceutical synthesis. Its unique chemical structure, a pyridine derivative with an amino and ester group, makes it an indispensable building block for a range of advanced therapeutic agents. For researchers and formulators, understanding its applications is key to unlocking new treatment possibilities.

One of the most significant uses of Methyl 2-aminonicotinate is in the development of novel oral poly(ADP-ribose)polymerase (PARP) inhibitors. Specifically, it is employed in the synthesis of compounds like MK-4827, which has shown remarkable efficacy in treating cancers driven by BRCA-1 and -2 mutations. This highlights the compound's importance in targeted cancer therapy, a rapidly growing field in pharmaceutical R&D.

Furthermore, Methyl 2-aminonicotinate serves as a precursor for synthesizing quinazolinone and quinazoline thione derivatives. These molecules are recognized for their potent phosphodiesterase 7 (PDE7) inhibitory activity. PDE7 inhibitors are of significant interest for their therapeutic potential in treating inflammatory conditions, autoimmune diseases, and certain neurological disorders. By providing reliable access to this key intermediate, suppliers and manufacturers enable crucial research in these areas.

For those looking to buy this essential chemical, partnering with reputable Chinese manufacturers ensures both quality and competitive pricing. The ability to purchase Methyl 2-aminonicotinate in varying quantities, from research-scale to bulk production, supports the entire lifecycle of drug development. As you plan your next synthesis project, consider the impact of this versatile intermediate and the benefits of sourcing from experienced chemical suppliers who can guarantee consistent supply and product integrity.