In the intricate world of organic synthesis, certain molecules stand out for their versatility and utility as building blocks. Methyl 3,4,5-trimethoxybenzoate (CAS: 1916-07-0) is one such compound, prized for its functional groups and structural arrangement that make it a valuable intermediate for a wide array of chemical reactions. This article examines the chemical properties and synthetic applications of Methyl 3,4,5-trimethoxybenzoate, offering insights for chemists and researchers seeking reliable sources for this compound.

Methyl 3,4,5-trimethoxybenzoate, presented as a white crystalline powder, possesses a molecular formula of C11H14O5 and a molecular weight of 226.23 g/mol. Its structure features a benzoic acid methyl ester core with three methoxy substituents at the 3, 4, and 5 positions. This arrangement of electron-donating methoxy groups influences the reactivity of the aromatic ring and the ester functionality, making it a useful synthon in organic chemistry.

The compound's physical and chemical properties contribute to its appeal. With a melting point of 82-84°C and a boiling point of 274-275°C, it exhibits good thermal stability, which is advantageous for reactions requiring elevated temperatures. Its flash point of 274-275°C further indicates a degree of safety in handling and processing. These specifications are critical for chemists performing complex multi-step syntheses, where intermediate stability is key to achieving high yields and desired product outcomes.

The synthesis of Methyl 3,4,5-trimethoxybenzoate typically begins with 3,4,5-trimethoxybenzoic acid, which is then esterified with methanol, often in the presence of an acid catalyst like sulfuric acid. This straightforward synthetic route, with reported yields of 100% under specific conditions, ensures its availability and cost-effectiveness. Researchers looking to buy Methyl 3,4,5-trimethoxybenzoate can often find competitive pricing from manufacturers specializing in fine chemical intermediates.

As a key intermediate, Methyl 3,4,5-trimethoxybenzoate finds application in various synthetic pathways. While its role in pharmaceutical synthesis, particularly for drugs like trimetozine and trimebutine maleate, is well-documented, its utility extends to other areas of organic chemistry. For instance, its structure makes it a potential precursor for creating specialty chemicals, agrochemical intermediates, or even advanced materials where tailored aromatic structures are required.

Chemists undertaking custom synthesis projects will find the chemical characteristics of Methyl 3,4,5-trimethoxybenzoate to be advantageous. Whether they are exploring novel reaction methodologies or developing new compounds, having a reliable CAS 1916-07-0 supplier is essential. Working with a recognized Methyl 3,4,5-trimethoxybenzoate manufacturer in China can provide access to high-quality material and expert technical support, streamlining the research and development process.

When sourcing this chemical, understanding its specifications, such as purity (often ≥99.0%) and low loss on drying (≤0.10%), is crucial. This ensures that the intermediate will perform reliably in subsequent reactions without introducing unwanted side products or reducing overall reaction efficiency. The ability to purchase Methyl 3,4,5-trimethoxybenzoate in bulk quantities with consistent quality is a significant advantage for industrial-scale synthesis.

In conclusion, Methyl 3,4,5-trimethoxybenzoate stands as a valuable component in the toolbox of organic chemists. Its well-defined properties and accessible synthesis make it an attractive intermediate for pharmaceutical and general organic synthesis. Securing this compound from reputable manufacturers and suppliers is key to advancing chemical research and production.