Monomethyl 5-nitroisophthalate (CAS 1955-46-0) is a fine chemical with significant utility across various scientific disciplines, primarily serving as a crucial intermediate in advanced chemical synthesis. Its molecular structure, characterized by a benzene ring substituted with one methyl ester, one carboxylic acid, and one nitro group, endows it with a unique reactivity profile, making it an attractive building block for chemists engaged in complex molecular design and development. As a reputable manufacturer and supplier, we provide this compound with high purity to meet the demanding requirements of the industry.

The synthesis of Monomethyl 5-nitroisophthalate is typically achieved through the selective esterification of 5-nitroisophthalic acid with methanol. This process requires careful control of reaction conditions to ensure the formation of the monoester rather than the diester. The resulting compound’s chemical properties make it exceptionally valuable. The presence of the nitro group offers a handle for reduction to an amine, a common transformation in organic synthesis that opens pathways to diverse functionalizations. Simultaneously, the remaining carboxylic acid group can be readily converted into amides, esters, or acid halides, facilitating the construction of complex pharmaceutical agents and novel materials.

In the pharmaceutical sector, Monomethyl 5-nitroisophthalate plays a pivotal role. It is a key intermediate in the synthesis of histone demethylase LSD1 inhibitors, compounds showing considerable promise in the treatment of various cancers. The precise structural features of this intermediate are critical for the efficacy and specificity of the final drug molecules. Furthermore, its application extends to the production of non-ionic X-ray contrast media, essential tools in modern medical imaging for diagnosing a wide range of conditions. The purity and consistent quality of the intermediate directly impact the performance and safety of these diagnostic agents.

Beyond pharmaceuticals, Monomethyl 5-nitroisophthalate is utilized in bioconjugation chemistry. Researchers employ it to synthesize heterotrifunctional crosslinkers, molecules designed to covalently link different biomolecules. This capability is fundamental for studying protein-protein interactions, developing antibody-drug conjugates (ADCs), and creating advanced diagnostic assays. In materials science, it serves as a monomer for creating specialized polyester resins. These polymers can be engineered for specific properties, such as enhanced thermal stability or improved mechanical strength, finding applications in high-performance coatings and advanced composites.

For R&D professionals and procurement specialists, sourcing Monomethyl 5-nitroisophthalate from reliable manufacturers is essential. Our commitment as a supplier in China is to deliver consistently high-quality product that meets stringent industry standards. By ensuring the purity and reliable availability of this versatile intermediate, we empower our clients to advance their research and development pipelines, leading to breakthroughs in medicine, diagnostics, and materials innovation.