In the intricate world of biochemical research, precise tools are indispensable for unraveling complex biological pathways. 2,4-Diamino-6-hydroxypyrimidine (CAS 56-06-4) stands out as a significant research chemical, primarily recognized for its potent inhibitory effect on GTP cyclohydrolase I (GCH1). This enzyme is central to the de novo synthesis of tetrahydrobiopterin (BH4), a critical cofactor involved in numerous physiological processes, including the synthesis of neurotransmitters and nitric oxide (NO). Understanding how to procure this compound from reputable suppliers is key for researchers aiming to conduct impactful studies.

Mechanism of Action and Research Applications

As a selective GCH1 inhibitor, 2,4-Diamino-6-hydroxypyrimidine effectively blocks the production of BH4. This blockade has profound implications for research into conditions influenced by BH4 levels, such as cardiovascular diseases, neurological disorders, and inflammatory responses. For instance, studies investigating the role of nitric oxide synthase (NOS) activity often utilize this compound to modulate NO production. By inhibiting BH4, 2,4-Diamino-6-hydroxypyrimidine helps researchers explore the intricate feedback mechanisms and cellular responses related to NO signaling. Its ability to suppress cytokine-induced NO synthesis makes it a valuable tool for studying inflammation and immune responses at a molecular level.

Researchers frequently seek this chemical for in vitro experiments, where precise control over enzyme activity is required. The compound's solubility in common research solvents like DMSO is also a critical factor for experimental design. When planning to purchase 2,4-Diamino-6-hydroxypyrimidine for laboratory use, it's important to confirm its purity, typically specified as 99.82% or higher by HPLC, to ensure reproducible and reliable results. Verified purity is a hallmark of quality from a trusted manufacturer.

Sourcing Strategies for Researchers

Securing a dependable supply of research chemicals is crucial for the continuity of scientific projects. For 2,4-Diamino-6-hydroxypyrimidine (CAS 56-06-4), researchers often turn to specialized chemical suppliers. When looking to buy this compound, prioritize suppliers who offer:

  • Comprehensive Product Information: Details on chemical properties, biological activity, storage conditions, and safety data sheets (SDS) are essential.
  • Quality Control Documentation: Availability of Certificates of Analysis (CoA) with lot-specific data assures the integrity of the compound.
  • Flexible Ordering Options: The ability to purchase in research-friendly quantities (e.g., 250 mg, 1 g) from a Chinese supplier can offer cost advantages.
  • Responsive Customer Service: Suppliers who can provide technical assistance and readily address inquiries regarding product specifications or ordering processes are invaluable partners.

By partnering with a reliable manufacturer or distributor, researchers can ensure they obtain high-quality 2,4-Diamino-6-hydroxypyrimidine, enabling them to conduct their studies with confidence. The availability of this compound from global suppliers, particularly those with strong manufacturing capabilities in regions like China, provides researchers with accessible resources to advance their scientific endeavors.