In the intricate world of pharmaceutical development, the selection of appropriate chemical intermediates is a cornerstone of successful drug discovery and manufacturing. 2-Fluoro-4-methoxybenzonitrile, identified by its CAS number 94610-82-9, is one such compound that has garnered significant attention due to its utility as a pharmaceutical intermediate. This white solid offers a unique chemical profile that empowers chemists to synthesize complex Active Pharmaceutical Ingredients (APIs) with greater precision and efficiency.

Chemical Identity and Properties

2-Fluoro-4-methoxybenzonitrile (C8H6FNO, Molecular Weight: 151.14) is characterized by the presence of a fluorine atom, a methoxy group, and a nitrile group attached to a benzene ring. This specific arrangement imparts valuable reactivity and stability, making it a sought-after building block. Its reported properties include a density of approximately 1.18 g/cm³, a boiling point around 233.9°C, and a flash point of 95.3°C. While its melting point can vary, it is typically encountered as a solid. These physical and chemical attributes are crucial for process chemists when designing synthesis routes.

Importance in API Synthesis

The primary application of 2-Fluoro-4-methoxybenzonitrile lies in its role as a precursor or intermediate in the synthesis of various APIs. The nitrile group (C≡N) is particularly versatile, capable of undergoing numerous transformations, such as hydrolysis to carboxylic acids, reduction to amines, or participation in cycloaddition reactions. The fluorine atom can enhance lipophilicity, metabolic stability, and binding affinity of the resulting drug molecules, while the methoxy group can influence solubility and electronic properties. This makes 2-Fluoro-4-methoxybenzonitrile an attractive starting material for medicinal chemists aiming to modulate the pharmacokinetic and pharmacodynamic profiles of potential drug candidates. For anyone looking to buy 2-Fluoro-4-methoxybenzonitrile for R&D, ensuring high purity is key to achieving reproducible results in API synthesis.

Market Dynamics and Supplier Considerations

The global demand for specialized pharmaceutical intermediates like 2-Fluoro-4-methoxybenzonitrile is steadily increasing, driven by advancements in drug discovery. Manufacturers, particularly those in China, play a pivotal role in meeting this demand. When selecting a CAS 94610-82-9 supplier, it is important to consider factors such as purity, consistency, production capacity, and regulatory compliance. A reliable 2-Fluoro-4-methoxybenzonitrile manufacturer will offer competitive pharmaceutical intermediate price points without compromising on quality. Engaging with a knowledgeable 2-Fluoro-4-methoxybenzonitrile supplier can also provide valuable technical support and insights into its application in your specific synthesis projects.

Conclusion

2-Fluoro-4-methoxybenzonitrile is more than just a chemical compound; it is an enabler of pharmaceutical innovation. Its strategic use in API synthesis allows for the development of more effective and targeted therapies. For companies involved in drug development, understanding the properties and sourcing options for this intermediate is crucial. By partnering with trusted suppliers who deliver high-quality 2-Fluoro-4-methoxybenzonitrile, pharmaceutical companies can accelerate their journey from discovery to market.