The efficacy and availability of essential medications often hinge on the complex chemical synthesis pathways that produce their active ingredients. At the heart of these pathways lie crucial intermediates, such as 4-Amino-2-chloro-6,7-dimethoxyquinazoline (CAS 23680-84-4). This compound plays an indispensable role in the manufacturing of Terazosin, a widely prescribed medication primarily used for treating hypertension and benign prostatic hyperplasia (BPH).

Understanding Terazosin and Its Synthesis

Terazosin is an alpha-1 adrenergic blocker, meaning it works by relaxing blood vessels, which lowers blood pressure. It also relaxes muscles in the prostate and bladder, easing urinary flow issues associated with BPH. The synthesis of Terazosin is a multi-step process, and 4-Amino-2-chloro-6,7-dimethoxyquinazoline represents a foundational building block. Its specific chemical structure provides the necessary quinazoline core and reactive sites for subsequent chemical modifications that ultimately lead to the final drug molecule.

The Chemical Significance of 4-Amino-2-chloro-6,7-dimethoxyquinazoline (CAS 23680-84-4)

The chemical formula C10H10ClN3O2 and a molecular weight of 239.66 define this off-white solid. The presence of the chlorine atom and the amino group on the quinazoline ring, coupled with the dimethoxy substitutions, makes it a highly reactive and versatile intermediate for organic synthesis. Specifically, the chlorine atom is a good leaving group, facilitating nucleophilic substitution reactions, which are common in constructing the complex piperazine ring system characteristic of Terazosin.

Procurement Considerations for Terazosin Manufacturers

For pharmaceutical companies involved in Terazosin production, securing a consistent and high-quality supply of 4-Amino-2-chloro-6,7-dimethoxyquinazoline is critical. When looking to buy this intermediate, several factors come into play:

  • Purity: High purity is non-negotiable to avoid carry-over impurities into the final API. Suppliers must demonstrate stringent quality control, often requiring ≥98% purity.
  • Reliable Supply: Consistent availability is essential to maintain production schedules. Working with experienced manufacturers who can guarantee supply, even for large orders, is vital.
  • Competitive Price: As a significant cost component in API synthesis, obtaining competitive pricing from a reputable manufacturer is a key objective.
  • Technical Support: Access to technical data and support from the supplier can be invaluable for process optimization and troubleshooting.

The Manufacturer's Role in the Supply Chain

Direct manufacturers of 4-Amino-2-chloro-6,7-dimethoxyquinazoline, particularly those located in China, often provide the most advantageous combination of quality, price, and supply reliability. By partnering with such suppliers, pharmaceutical companies can streamline their procurement process and reduce costs associated with sourcing this vital intermediate. Engaging with these suppliers for a quote and exploring bulk purchase options are recommended steps for any company utilizing this chemical in their synthesis routes.

In summary, 4-Amino-2-chloro-6,7-dimethoxyquinazoline (CAS 23680-84-4) is more than just a chemical compound; it is a cornerstone in the production of a significant therapeutic agent. Understanding its chemical properties and the importance of sourcing it from dependable manufacturers is key for ensuring the continued availability of essential medicines.