In the realm of modern organic synthesis, the precise engineering of complex molecules is a hallmark of innovation, particularly in the pharmaceutical and agrochemical sectors. Central to this endeavor are versatile chemical intermediates that offer specific functionalities and reactivity. Among these, 4-Bromo-2-(trifluoromethyl)benzonitrile (CAS: 191165-13-6) has emerged as a critical building block, prized for its unique structural features that enable a wide array of synthetic transformations. As a dedicated manufacturer and supplier operating from China, we are committed to providing this high-value compound to facilitate cutting-edge chemical research and development.

The chemical structure of 4-Bromo-2-(trifluoromethyl)benzonitrile—featuring a bromine atom, a nitrile group, and a trifluoromethyl substituent on a benzene ring—renders it exceptionally useful in constructing diverse molecular architectures. The bromine atom serves as an excellent leaving group or handle for various palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura, Heck, and Sonogashira couplings. These reactions are fundamental in forming new carbon-carbon bonds, allowing for the efficient attachment of aryl, vinyl, or alkynyl fragments, thereby expanding molecular complexity.

The nitrile group (-CN) is another reactive site, capable of undergoing hydrolysis to carboxylic acids, reduction to amines, or addition reactions. This duality of reactivity makes 4-Bromo-2-(trifluoromethyl)benzonitrile a strategic intermediate for creating substituted phenylacetic acids, anilines, and other valuable functionalized aromatic compounds. Its primary established use is in the synthesis of 4-Bromo-2-(trifluoromethyl)phenylacetic Acid, a derivative that finds application in further synthetic endeavors, often leading to active pharmaceutical ingredients (APIs).

The trifluoromethyl group (-CF3) is a highly sought-after substituent in medicinal chemistry and agrochemistry. Its strong electron-withdrawing nature influences the electronic properties of the molecule, while its lipophilicity can enhance cell membrane permeability and improve metabolic stability. When you choose to buy 4-Bromo-2-(trifluoromethyl)benzonitrile from us, you are acquiring a reagent that carries these valuable attributes, ready to be incorporated into molecules designed for biological activity or specific material properties.

For organizations looking to purchase this advanced intermediate, partnering with a reliable manufacturer from China offers distinct advantages, including competitive pricing and assured supply chain integrity. Our rigorous quality control processes ensure that each batch meets stringent purity standards, critical for the success of complex, multi-step syntheses. We encourage researchers and development teams to consider our 4-Bromo-2-(trifluoromethyl)benzonitrile for their next groundbreaking project. Contact us for a quote and to explore how we can support your synthetic challenges.