In the intricate world of pharmaceutical development, the selection of reliable and effective chemical intermediates is a cornerstone of success. 4-Hydroxy-1,3-Isobenzofurandione (CAS 37418-88-5) is one such compound, offering valuable functionalities for synthetic chemists. As a premier manufacturer and supplier, we understand the critical requirements of the pharmaceutical sector and are committed to providing materials that meet rigorous standards. This article delves into why this compound is important and how R&D professionals can effectively source it.

Chemical Profile and Significance

4-Hydroxy-1,3-Isobenzofurandione, with its distinct molecular structure (C8H4O4), presents unique reactivity due to its anhydride and hydroxyl functionalities. Typically supplied as a beige powder with a purity of 98%, it serves as an excellent starting material or intermediate in the synthesis of more complex active pharmaceutical ingredients (APIs). Its molecular weight of 164.11 g/mol is a key identifier for chemists involved in stoichiometric calculations.

Applications in Drug Discovery and Manufacturing

The utility of 4-Hydroxy-1,3-Isobenzofurandione within the pharmaceutical landscape is diverse:

  • API Synthesis: Its functional groups allow for various chemical transformations, including esterification, amidation, and ring-opening reactions, which are fundamental steps in building complex API structures. Researchers often search for this compound when developing novel therapeutic agents.
  • Building Block for Specialty Chemicals: Beyond direct API synthesis, it can be used to create specialized reagents or building blocks that are themselves critical components in drug discovery pipelines.
  • Research and Development: For academic institutions and biotech firms, acquiring this chemical is essential for exploring new synthetic pathways and potential drug candidates. Buying this intermediate from a reputable source ensures that research is built upon a foundation of high-quality materials.

Procurement Best Practices for Pharmaceutical Intermediates

When procuring pharmaceutical intermediates like 4-Hydroxy-1,3-Isobenzofurandione, several best practices should be followed:

  • Supplier Vetting: Choose manufacturers and suppliers with a proven track record in the pharmaceutical chemical supply chain. Look for ISO certifications and adherence to Good Manufacturing Practices (GMP) where applicable.
  • Quality Documentation: Always request and review the Certificate of Analysis (COA) for each batch to confirm purity, impurity profiles, and physical characteristics.
  • Supply Chain Stability: Ensure your chosen supplier can provide consistent quality and quantity, minimizing disruptions to your production schedule. Exploring suppliers in China can offer advantages in terms of scale and cost-effectiveness.
  • Technical Support: A good supplier will offer technical support to address any queries regarding the chemical's properties, handling, or potential synthetic routes.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supporting the pharmaceutical industry by providing high-quality 4-Hydroxy-1,3-Isobenzofurandione. As a trusted manufacturer and supplier, we are equipped to meet the demanding requirements of drug development and manufacturing. Contact us today to inquire about pricing, samples, and how we can be your reliable partner for pharmaceutical intermediates.