In the intricate world of pharmaceutical development, the selection of high-quality chemical building blocks is fundamental to creating effective and safe medications. 4-Hydroxybenzoyl Chloride (CAS 28141-24-4) has carved out a significant niche as a critical intermediate, particularly in the fight against viral infections. For research scientists and product formulators, understanding its applications and sourcing it efficiently is key to advancing drug discovery.

4-Hydroxybenzoyl Chloride: A Versatile Chemical Intermediate

As a derivative of benzoyl chloride, 4-Hydroxybenzoyl Chloride possesses reactive functional groups that make it highly valuable in organic synthesis. Its structure allows for various chemical transformations, making it an indispensable precursor for a range of complex molecules. The presence of both a hydroxyl group and an acyl chloride moiety offers chemists multiple avenues for derivatization, leading to a diverse array of downstream products.

Key Application: HIV-Protease Inhibitors

One of the most significant applications of 4-Hydroxybenzoyl Chloride is its role in the synthesis of HIV-protease inhibitors. These drugs are vital components of antiretroviral therapy, helping to manage the Human Immunodeficiency Virus (HIV) infection by blocking the virus's ability to replicate. The compound serves as a precursor in the creation of specific lysine sulfonamides, which are engineered to inhibit the viral protease enzyme. This precise application highlights the importance of sourcing a highly pure and consistently available supply of 4-Hydroxybenzoyl Chloride to ensure the effectiveness of these life-saving medications.

Sourcing Considerations for R&D and Manufacturing

When engaging in drug development that requires 4-Hydroxybenzoyl Chloride, consider the following points:

  • Supplier Vetting: Always partner with reputable chemical manufacturers and suppliers. Look for those that can provide detailed technical data, including purity levels (typically 99% min) and relevant safety information. Access to a reliable 4-hydroxybenzoyl chloride manufacturer is crucial.
  • Quantity and Lead Times: Whether for laboratory research or large-scale production, ensure your chosen supplier can meet your quantity needs and delivery timelines. Companies in China often offer substantial supply capacities and efficient logistics.
  • Cost-Effectiveness: Researching the market for the best 4-hydroxybenzoyl chloride price can lead to significant cost savings without compromising on quality. Comparing quotes from various international suppliers is a smart procurement strategy.
  • Technical Support: A good supplier can offer technical support, assisting with inquiries regarding product specifications, handling, and potential applications.

The consistent availability of high-quality 4-Hydroxybenzoyl Chloride from trusted sources empowers pharmaceutical companies to continue their vital work in developing new treatments and improving existing therapies. As you plan your next research project or manufacturing run, remember the importance of this intermediate and choose your suppliers wisely.