The Role of 5-Bromo-1,3-dimethyl-2,6-dioxopyrimidine-4-carboxylic Acid in Organic Synthesis
In the realm of organic chemistry, the development of novel compounds relies heavily on versatile building blocks. 5-Bromo-1,3-dimethyl-2,6-dioxopyrimidine-4-carboxylic acid (CAS: 4623-25-0) stands out as a significant heterocyclic intermediate, offering unique reactive sites for complex molecular construction. Its pyrimidine core, functionalized with a bromine atom and a carboxylic acid group, makes it an invaluable reagent for chemists aiming to synthesize advanced materials and pharmaceutical candidates.
Chemical Properties and Reactivity: With a molecular formula of C7H7BrN2O4 and a molecular weight of 263.05, this compound presents a stable structure under standard conditions. The bromine atom at the 5-position of the pyrimidine ring is susceptible to various nucleophilic substitution and cross-coupling reactions, such as Suzuki, Stille, or Heck couplings. These reactions are fundamental for carbon-carbon bond formation, enabling the creation of intricate molecular architectures. The carboxylic acid group provides another handle for functionalization, allowing for esterification, amidation, or decarboxylation reactions.
Applications in Research and Development: Researchers frequently turn to this intermediate for its utility in synthesizing bioactive molecules and functional materials. Its integration into larger molecular frameworks can lead to compounds with potential applications in medicinal chemistry, agrochemicals, and material science. For instance, it can serve as a precursor for creating derivatives with targeted biological activities or specific electronic properties.
Sourcing the Intermediate: Acquiring high-quality 5-Bromo-1,3-dimethyl-2,6-dioxopyrimidine-4-carboxylic acid is crucial for reproducible research outcomes. Reputable manufacturers, particularly those in China, are key suppliers. When you search to buy this compound, ensure the supplier can provide detailed specifications, including purity (typically 95% min), and reliable technical data. NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier committed to delivering premium chemical intermediates to the global market. We encourage you to inquire about our product's availability, pricing, and sample options to support your ongoing synthetic endeavors.
Perspectives & Insights
Alpha Spark Labs
“The bromine atom at the 5-position of the pyrimidine ring is susceptible to various nucleophilic substitution and cross-coupling reactions, such as Suzuki, Stille, or Heck couplings.”
Future Pioneer 88
“These reactions are fundamental for carbon-carbon bond formation, enabling the creation of intricate molecular architectures.”
Core Explorer Pro
“The carboxylic acid group provides another handle for functionalization, allowing for esterification, amidation, or decarboxylation reactions.”