The intricate world of pharmaceutical development relies heavily on a diverse array of chemical building blocks. Among these, 5-Bromobenzene-1,3-diamine (CAS 33786-90-2) stands out as a critical intermediate. For pharmaceutical researchers and procurement specialists, understanding its role and ensuring a reliable supply chain is vital for driving innovation and drug discovery.

Understanding the Chemical Structure and Properties

5-Bromobenzene-1,3-diamine, with its molecular formula C6H7BrN2 and CAS number 33786-90-2, is characterized by a benzene ring substituted with a bromine atom and two amine groups in a meta configuration. This specific arrangement of functional groups imparts unique reactivity, making it an invaluable precursor in complex organic synthesis.

Applications in Pharmaceutical Synthesis

The primary significance of 5-Bromobenzene-1,3-diamine lies in its utility as a key intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). The presence of both the bromine atom and the amine functionalities allows for a wide range of chemical transformations:

  • Coupling Reactions: The bromine atom can readily participate in various cross-coupling reactions, such as Suzuki, Heck, or Sonogashira couplings, enabling the introduction of diverse substituents onto the benzene ring.
  • Amine Functionalization: The amine groups can be further modified through acylation, alkylation, or other reactions to build more complex molecular structures essential for drug efficacy.
  • Heterocyclic Synthesis: It can be used as a starting material for constructing various nitrogen-containing heterocyclic rings, which are common scaffolds in many pharmaceutical drugs.

Researchers and product formulators often seek high-purity grades of this compound, typically 97% or 99%, to ensure the integrity and efficacy of the final pharmaceutical product. Reliable sourcing from manufacturers who can guarantee these purity levels is paramount.

Sourcing and Commercial Aspects

For those looking to purchase 5-Bromobenzene-1,3-diamine for pharmaceutical research and development, identifying a dependable manufacturer and supplier is key. Companies specializing in fine chemicals and pharmaceutical intermediates, particularly those in China, often provide these materials. When inquiring about purchasing this compound, it is important to ask about:

  • Purity and Analytical Data: Request a Certificate of Analysis (CoA) detailing the purity and impurity profile.
  • Supply Chain Stability: Confirm the manufacturer's production capacity and ability to fulfill ongoing requirements.
  • Pricing and Terms: Obtain quotes that clearly outline the price per unit (e.g., per gram or kilogram) and associated payment and delivery terms (e.g., L/C, T/T, FOB).

NINGBO INNO PHARMCHEM CO.,LTD., as a manufacturer and supplier, offers 5-Bromobenzene-1,3-diamine with a focus on high purity and reliable supply, catering to the stringent demands of the pharmaceutical industry. Ensuring a robust supply of such intermediates is a cornerstone of successful drug development.

In summary, 5-Bromobenzene-1,3-diamine (CAS 33786-90-2) plays an indispensable role in pharmaceutical synthesis, enabling the creation of complex and vital medicinal compounds. Its strategic procurement from trustworthy manufacturers is a critical step for any pharmaceutical company.