Pantoprazole, a widely prescribed medication for treating conditions like acid reflux and ulcers, relies on a precise and well-controlled synthetic pathway. Central to this process is the intermediate 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole (CAS 97963-62-7). Understanding the properties and sourcing of this compound is essential for any pharmaceutical company involved in Pantoprazole manufacturing.

Chemical Identity and Properties

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole, with the molecular formula C8H6F2N2OS and molecular weight of 216.21, is characterized by its off-white to pale yellow powder appearance. Its melting point typically falls between 239-243 °C. The high purity, often exceeding 98.0%, is a critical factor for its effective use in subsequent pharmaceutical synthesis steps.

Synthesis Pathway of Pantoprazole

The synthesis of Pantoprazole commonly involves the coupling of 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole with 2-chloromethyl-3,4-dimethoxypyridine hydrochloride, followed by an oxidation step. The quality and consistency of the starting intermediate directly impact the yield, purity, and overall efficiency of the final API production. This makes the selection of a reliable 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole supplier non-negotiable.

Sourcing Considerations for Pharmaceutical Manufacturers

When looking to purchase 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole, pharmaceutical manufacturers should prioritize:

  • Purity and Quality Control: Always request a Certificate of Analysis (CoA) confirming the purity (≥98.0%) and adherence to established specifications. Consistent batch-to-batch quality is crucial.
  • Supplier Reliability: Partner with experienced manufacturers and suppliers who can guarantee a stable supply chain and timely delivery. Companies with a strong presence in major chemical manufacturing hubs like China are often well-positioned.
  • Regulatory Compliance: Ensure the supplier can provide necessary documentation for regulatory submissions, if applicable.
  • Competitive Pricing: Obtain quotes from multiple reputable sources to ensure cost-effectiveness without compromising on quality. The price of CAS 97963-62-7 can vary based on purity and supplier.

Applications Beyond Pantoprazole

While its primary role is as a Pantoprazole intermediate, 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole can also serve as a valuable building block in other areas of medicinal chemistry and organic synthesis, particularly in research and development for new drug candidates or specialized fine chemicals.

For pharmaceutical companies seeking to optimize their Pantoprazole production, securing a high-quality supply of 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole is a fundamental step. By focusing on the right specifications and partnering with trusted manufacturers, you can ensure the integrity and success of your API manufacturing process.