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The application of azetidine in drug design is rooted in the principle of reducing molecular flexibility. Unlike more flexible acyclic structures, the cyclic nature of azetidine imposes specific spatial orientations on attached functional groups. This pre-organization can minimize the entropic cost of binding, thereby increasing the overall binding affinity of a drug candidate. For researchers looking to purchase such advanced building blocks, NINGBO INNO PHARMCHEM CO.,LTD. ensures a reliable supply of these vital components. The strategic incorporation of azetidine can lead to more potent and selective drugs, reducing off-target effects and improving patient outcomes.

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