In the intricate world of organic synthesis, specific molecular building blocks are indispensable for constructing complex molecules. (R)-3-(tert-Butyl)-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole, identified by CAS number 1338454-03-7, stands out as a valuable chiral intermediate. Its unique structure and stereochemistry make it a sought-after compound for researchers engaged in advanced chemical synthesis, particularly within the pharmaceutical sector. Understanding its properties and applications is key for any chemist looking to procure this specialized material.

Understanding the Chemical Profile

This oxaphosphole derivative possesses a chiral center, making it a critical component in enantioselective synthesis. The presence of the tert-butyl group and the dimethoxyphenyl moiety contributes to its specific reactivity and steric profile. As a light-yellow crystalline solid, it is typically stored under inert conditions to maintain its integrity. When chemists seek to buy this compound, they are often looking for a reliably pure form to ensure the success of multi-step synthetic procedures. Manufacturers specializing in fine chemicals and pharmaceutical intermediates are the primary source for this material.

Applications in Modern Synthesis

The primary utility of (R)-3-(tert-Butyl)-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole lies in its application as a chiral building block. It is frequently employed in:

  • Pharmaceutical R&D: Essential for the synthesis of complex Active Pharmaceutical Ingredients (APIs) where specific stereochemistry is crucial for biological activity.
  • Asymmetric Catalysis: Its structural features may lend themselves to the development of novel chiral ligands or catalysts used in asymmetric transformations.
  • Materials Science: The unique electronic and steric properties could be explored in the development of advanced functional materials.

For scientists actively involved in these fields, locating a dependable supplier who can guarantee consistent quality and availability is paramount. Purchasing this intermediate from a reputable manufacturer ensures that the research and development process is not hindered by material inconsistencies.

Procurement Tips for Researchers

When considering the purchase of (R)-3-(tert-Butyl)-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole, R&D professionals should:

  • Verify CAS Number: Always confirm the CAS number (1338454-03-7) to ensure you are ordering the correct compound.
  • Request Quotes: Contacting manufacturers or suppliers directly for quotes allows for competitive pricing and discussion of bulk order requirements.
  • Check Purity Specifications: Ensure the purity meets your project's demands. Look for suppliers who provide detailed Certificates of Analysis.
  • Consider Lead Times: Understand the typical lead times for delivery, especially for international orders, to align with your project timelines.

By understanding the role of this specialized chiral intermediate and knowing where to buy it from reliable sources, chemists can effectively advance their synthetic chemistry projects.