In the dynamic field of synthetic chemistry, particularly within pharmaceutical and life sciences research, the strategic incorporation of fluorine into organic molecules has proven to be a powerful tool. Fluorinated amino acids, such as Boc-Phe(3,5-DiF)-OH (CAS 205445-52-9), are prime examples of how targeted modifications can yield compounds with enhanced properties. This article delves into the significance of fluorinated amino acids and highlights Boc-Phe(3,5-DiF)-OH as a key intermediate, providing insights for those looking to buy.

The Advantage of Fluorine in Biomolecules

Fluorine's unique properties – its high electronegativity, small size, and ability to form strong carbon-fluorine bonds – allow it to significantly impact a molecule's biological and chemical behavior. When incorporated into amino acids, these effects can include:

  • Increased Metabolic Stability: The C-F bond is highly resistant to enzymatic cleavage, prolonging the half-life of peptides and proteins in vivo.
  • Altered pKa Values: Fluorine can influence the acidity or basicity of nearby functional groups, affecting molecular interactions.
  • Enhanced Lipophilicity: Fluorinated compounds often exhibit increased lipophilicity, which can improve cell membrane permeability and oral bioavailability.
  • Modified Conformation: Fluorine substitution can subtly alter a molecule's three-dimensional structure, potentially improving binding affinity to target receptors.

Boc-Phe(3,5-DiF)-OH embodies these advantages, with the two fluorine atoms on the phenyl ring of phenylalanine providing these beneficial modifications. This makes it a sought-after intermediate for researchers aiming to fine-tune the properties of peptides and drug candidates.

Sourcing Boc-Phe(3,5-DiF)-OH: What to Look For

As a critical component for advanced synthesis, the availability of high-quality Boc-Phe(3,5-DiF)-OH is essential. When considering where to buy this intermediate:

  • Manufacturer Specialization: Opt for suppliers that specialize in amino acid derivatives and custom synthesis, ensuring they have the expertise to produce compounds with stringent purity requirements.
  • Purity and Analytical Data: Always verify the purity (typically 99%+) and review provided analytical data such as HPLC and NMR.
  • Bulk Purchase Options: For ongoing research or pilot-scale production, inquire about bulk pricing and supply capabilities from manufacturers.
  • Global Supply Network: Many leading manufacturers are based in China, offering competitive pricing and efficient global shipping for those needing to buy these advanced chemical building blocks.

By understanding the unique benefits of fluorinated amino acids and partnering with reliable manufacturers, researchers can effectively leverage compounds like Boc-Phe(3,5-DiF)-OH to drive innovation in their fields. When you're ready to buy, engage with experienced suppliers to ensure you receive the quality and quantity you need.